Standard Name	BBC1 1
Systematic Name	YJL020C
Alias	MTI1 2 , YJL021C
Feature Type	ORF, Verified
Description	Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches (2, 3)
Name Description	Bni1 synthetic lethal and Bee1 (las17) Complex member 4

Chromosomal Location	ChrX:402410 to 398937 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for BBC1
Molecular Function
Manually curated	myosin I binding (IPI)
Biological Process
Manually curated	actin cytoskeleton organization (IGI, IPI)
Cellular Component
Manually curated	actin cortical patch (IDA)

Classical genetics
null	endocytosis: decreased viable
Large-scale survey
null	competitive fitness: decreased endocytosis: decreased haploinsufficient heat sensitivity: increased resistance to cycloheximide: decreased resistance to amitrole: decreased resistance to bleomycin: increased resistance to hydroxyurea: increased resistance to methyl methanesulfonate: decreased resistance to tunicamycin: decreased resistance to camptothecin: decreased viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	202 total interaction(s) for 126 unique genes/features.
Physical Interactions	Affinity Capture-MS: 20 Affinity Capture-RNA: 2 Affinity Capture-Western: 2 Biochemical Activity: 4 PCA: 7 Protein-peptide: 1 Reconstituted Complex: 2 Two-hybrid: 59
Genetic Interactions	Negative Genetic: 46 Phenotypic Enhancement: 4 Positive Genetic: 4 Synthetic Growth Defect: 14 Synthetic Lethality: 36 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrX:402410 to 398937 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	This feature contains embedded feature(s): YJL021C | YJL020W-A
Last Update	Coordinates: 2011-02-03 | Sequence: 2001-06-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3474 402410..398937 2011-02-03 2001-06-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez)

Primary SGDID	S000003557