IMA1/YGR287C Summary

IMA1/YGR287C Summary

Standard Name	IMA1 1, 2
Systematic Name	YGR287C
Feature Type	ORF, Verified
Description	Major isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); required for isomaltose utilization; specificity for isomaltose, alpha-methylglucoside, and palatinose; member of the IMA isomaltase family (1, 2, 3, 4, 5, 6, 7)
Name Description	IsoMAltase 1, 2

Chromosomal Location	ChrVII:1068991 to 1067222 \| ORF Map \| GBrowse
	Note: this feature is encoded on the Crick strand.

Gene Ontology Annotations All IMA1 GO evidence and references

	View Computational GO annotations for IMA1
Molecular Function
Manually curated	oligo-1,6-glucosidase activity (IDA)
Biological Process
Manually curated	disaccharide catabolic process (IGI, IMP)
Cellular Component
High-throughput	mitochondrion (IDA) colocalizes_with ribosome (IDA)

Mutant phenotypes All IMA1 Phenotype evidence and references

Classical genetics
null	utilization of carbon source: absent
Large-scale survey
null	competitive fitness: increased haploinsufficient resistance to streptomycin: decreased resistance to cycloheximide: decreased starvation resistance: decreased viable
overexpression	resistance to sirolimus: increased
Resources	PROPHECY \| SCMD \| ScreenTroll \| Yeast Fitness Database

interactions All IMA1 Interaction evidence and references

	35 total interaction(s) for 35 unique genes/features.
Physical Interactions	Protein-peptide: 5 Reconstituted Complex: 6
Genetic Interactions	Negative Genetic: 18 Phenotypic Enhancement: 1 Positive Genetic: 1 Synthetic Growth Defect: 1 Synthetic Lethality: 2 Synthetic Rescue: 1
Resources	BioGRID \| BOND \| BioPIXIE \| CYC2008 (complexes) \| Complexome \| DRYGIN \| GeneMANIA \| InterologFinder

Expression Summary


Resources	Expression Summary \| Cell cycle and metabolic oscillation \| Cell cycle transcript profile \| Cyclebase \| Genevestigator \| GermOnline \| SPELL \| YMGV \| YeastFunc

Protein Information All IMA1 Protein evidence and references

Localization	YPL+ \| YeastGFP
Phosphorylation	PhosphoGRID \| PhosphoPep Database
Structure	GPMDB \| SCOP \| YeastRC
Homologs	Ashbya (AGD) \| AspGD Homologs \| CGD Homologs \| CandidaDB Homologs \| Fungal Orthogroups Repository \| P-POD \| PDB Homologs \| PhylomeDB \| YGOB \| YOGY

sequence information

ChrVII:1068991 to 1067222 | |

Note: this feature is encoded on the Crick strand.

SGD ORF map

Last Update

Coordinates: 2011-02-03 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1770	1068991..1067222	2011-02-03	1996-07-31

Retrieve sequences

Analyze Sequence

S288C only	BLASTP \| ATCC/WashU Clones \| BLASTN \| Design Primers \| Restriction Fragment Map \| Restriction Fragment Sizes \| Six-Frame Translation
S288C vs. other species	Fungal Alignment \| BLASTN vs. fungi \| BLASTP at NCBI \| BLASTP vs. fungi \| Synteny Viewer
S288C vs. other strains	Strain Alignment

Resources

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| Search all NCBI (Entrez) \| UniProtKB

Primary SGDID	S000003519

References cited on this page View Complete Literature Guide for IMA1

1)	Teste MA, et al. (2010) Characterization of a New Multigene Family Encoding Isomaltases in the Yeast Saccharomyces cerevisiae, the IMA Family. J Biol Chem 285(35):26815-24
2)	Naumoff DG and Naumov GI (2010) Discovery of a novel family of alpha-glucosidase IMA genes in yeast Saccharomyces cerevisiae. Dokl Biochem Biophys 432():114-6
3)	Sickmann A, et al. (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12
4)	Fleischer TC, et al. (2006) Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Genes Dev 20(10):1294-307
5)	Reinders J, et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54
6)	Yamamoto K, et al. (2004) Val216 decides the substrate specificity of alpha-glucosidase in Saccharomyces cerevisiae. Eur J Biochem 271(16):3414-20
7)	Brown CA, et al. (2010) Rapid expansion and functional divergence of subtelomeric gene families in yeasts. Curr Biol 20(10):895-903