BGL2/YGR282C Summary Help

BGL2 BASIC INFORMATION

Standard Name BGL2 1
Systematic Name YGR282C
Feature Type ORF, Verified
Description Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance (2 and see Summary Paragraph)
Name Description Beta-GLucanase 1
GO Annotations All BGL2 GO evidence and references
    View Computational GO annotations for BGL2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All BGL2 Phenotype details and references
Classical genetics
null
Large-scale survey
null
overexpression
Interactions BGL2 All interactions details and references
12 total interaction(s) for 11 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 1
Genetic Interactions
  • Dosage Lethality: 1
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 2
  • Synthetic Rescue: 1
Sequence Information
ChrVII:1058731 to 1057790 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2007-12-11 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..942 1058731..1057790 2007-12-11 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003514

BGL2 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Protein Info & Structure
  • Localization Resources
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for BGL2

SUMMARY PARAGRAPH for BGL2

BGL2 encodes an endo-beta-1,3-glucanase that is abundant in the yeast cell wall; it introduces intrachain 1,6-beta linkages into 1,3-beta glucan, contributing to the rigid structure of the cell wall (1, 2). Null bgl2 mutants are viable, but overproduction of Bgl2p leads to defects in the cell wall and sensitivity to osmotic stress (3, 2, 1). Homologs of BGL2 have been found in many other fungi, including Candida albicans and Aspergillus fumigatus (4, 5).

Last updated: 1999-12-31

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for BGL2]

1) Klebl F and Tanner W  (1989) Molecular cloning of a cell wall exo-beta-1,3-glucanase from Saccharomyces cerevisiae. J Bacteriol 171(11):6259-64
2) Mrsa V, et al.  (1993) Purification and characterization of the Saccharomyces cerevisiae BGL2 gene product, a cell wall endo-beta-1,3-glucanase. J Bacteriol 175(7):2102-6
3) Shimizu J, et al.  (1994) The hypo-osmolarity-sensitive phenotype of the Saccharomyces cerevisiae hpo2 mutant is due to a mutation in PKC1, which regulates expression of beta-glucanase. Mol Gen Genet 242(6):641-8
4) Sarthy AV, et al.  (1997) Phenotype in Candida albicans of a disruption of the BGL2 gene encoding a 1,3-beta-glucosyltransferase. Microbiology 143 ( Pt 2):367-76
5) Mouyna I, et al.  (1998) A 1,3-beta-glucanosyltransferase isolated from the cell wall of Aspergillus fumigatus is a homologue of the yeast Bgl2p. Microbiology 144 ( Pt 11):3171-80