BGL2/YGR282C Summary Help

Standard Name BGL2 1
Systematic Name YGR282C
Alias SCW9 2
Feature Type ORF, Verified
Description Endo-beta-1,3-glucanase; major protein of the cell wall, involved in cell wall maintenance; involved in incorporation of newly synthesized mannoprotein molecules into the cell wall (3, 4 and see Summary Paragraph)
Name Description Beta-GLucanase 1
Chromosomal Location
ChrVII:1058724 to 1057783 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All BGL2 GO evidence and references
  View Computational GO annotations for BGL2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 5 genes
Classical genetics
Large-scale survey
77 total interaction(s) for 68 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 19
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 3
  • Biochemical Activity: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Lethality: 2
  • Negative Genetic: 35
  • Phenotypic Enhancement: 3
  • Positive Genetic: 5
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 1
  • Synthetic Rescue: 2

Expression Summary
Length (a.a.) 313
Molecular Weight (Da) 34,118
Isoelectric Point (pI) 4.16
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrVII:1058724 to 1057783 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..942 1058724..1057783 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003514

BGL2 encodes an endo-beta-1,3-glucanase that is abundant in the yeast cell wall; it introduces intrachain 1,6-beta linkages into 1,3-beta glucan, contributing to the rigid structure of the cell wall (1, 3). Null bgl2 mutants are viable, but overproduction of Bgl2p leads to defects in the cell wall and sensitivity to osmotic stress (5, 3, 1). Homologs of BGL2 have been found in many other fungi, including Candida albicans and Aspergillus fumigatus (6, 7).

Last updated: 1999-12-31 Contact SGD

References cited on this page View Complete Literature Guide for BGL2
1) Klebl F and Tanner W  (1989) Molecular cloning of a cell wall exo-beta-1,3-glucanase from Saccharomyces cerevisiae. J Bacteriol 171(11):6259-64
2) Cappellaro C, et al.  (1998) New potential cell wall glucanases of Saccharomyces cerevisiae and their involvement in mating. J Bacteriol 180(19):5030-7
3) Mrsa V, et al.  (1993) Purification and characterization of the Saccharomyces cerevisiae BGL2 gene product, a cell wall endo-beta-1,3-glucanase. J Bacteriol 175(7):2102-6
4) Plotnikova TA, et al.  (2006) Bgl2p and Gas1p are the major glucan transferases forming the molecular ensemble of yeast cell wall. Dokl Biochem Biophys 409():244-7
5) Shimizu J, et al.  (1994) The hypo-osmolarity-sensitive phenotype of the Saccharomyces cerevisiae hpo2 mutant is due to a mutation in PKC1, which regulates expression of beta-glucanase. Mol Gen Genet 242(6):641-8
6) Sarthy AV, et al.  (1997) Phenotype in Candida albicans of a disruption of the BGL2 gene encoding a 1,3-beta-glucosyltransferase. Microbiology 143 ( Pt 2):367-76
7) Mouyna I, et al.  (1998) A 1,3-beta-glucanosyltransferase isolated from the cell wall of Aspergillus fumigatus is a homologue of the yeast Bgl2p. Microbiology 144 ( Pt 11):3171-80