YOR1/YGR281W Summary Help

Standard Name YOR1 1
Systematic Name YGR281W
Alias YRS1 2
Feature Type ORF, Verified
Description Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter mediates export of many different organic anions including oligomycin; homolog of human cystic fibrosis transmembrane receptor (CFTR) (1, 2, 3, 4, 5, 6)
Name Description Yeast Oligomycin Resistance 1
Chromosomal Location
ChrVII:1052824 to 1057257 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All YOR1 GO evidence and references
  View Computational GO annotations for YOR1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 8 genes
Resources
Classical genetics
overexpression
reduction of function
Large-scale survey
null
unspecified
Resources
355 total interaction(s) for 328 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 25
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 1
  • Biochemical Activity: 1
  • Co-fractionation: 2
  • PCA: 33
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 134
  • Phenotypic Enhancement: 7
  • Phenotypic Suppression: 3
  • Positive Genetic: 136
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 2
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,477
Molecular Weight (Da) 166,727
Isoelectric Point (pI) 7.65
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:1052824 to 1057257 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..4434 1052824..1057257 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000003513
References cited on this page View Complete Literature Guide for YOR1
1) Katzmann DJ, et al.  (1995) Expression of an ATP-binding cassette transporter-encoding gene (YOR1) is required for oligomycin resistance in Saccharomyces cerevisiae. Mol Cell Biol 15(12):6875-83
2) Cui Z, et al.  (1996) The multidrug resistance-associated protein (MRP) subfamily (Yrs1/Yor1) of Saccharomyces cerevisiae is important for the tolerance to a broad range of organic anions. J Biol Chem 271(25):14712-6
3) Decottignies A, et al.  (1998) ATPase and multidrug transport activities of the overexpressed yeast ABC protein Yor1p. J Biol Chem 273(20):12612-22
4) Rogers B, et al.  (2001) The pleitropic drug ABC transporters from Saccharomyces cerevisiae. J Mol Microbiol Biotechnol 3(2):207-14
5) Epping EA and Moye-Rowley WS  (2002) Identification of interdependent signals required for anterograde traffic of the ATP-binding cassette transporter protein Yor1p. J Biol Chem 277(38):34860-9
6) Louie RJ, et al.  (2012) A yeast phenomic model for the gene interaction network modulating CFTR-?F508 protein biogenesis. Genome Med 4(12):103