YTA7/YGR270W Summary Help

Standard Name YTA7 1
Systematic Name YGR270W
Feature Type ORF, Verified
Description Protein that localizes to chromatin; has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; relocalizes to the cytosol in response to hypoxia; potentially phosphorylated by Cdc28p (2, 3, 4, 5, 6)
Name Description Yeast Tat-binding Analog 1
Chromosomal Location
ChrVII:1027370 to 1031509 | ORF Map | GBrowse
Gene Ontology Annotations All YTA7 GO evidence and references
  View Computational GO annotations for YTA7
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 5 genes
Classical genetics
Large-scale survey
486 total interaction(s) for 298 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 117
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 2
  • Biochemical Activity: 1
  • Co-fractionation: 1
  • Co-localization: 2
  • PCA: 1
  • Protein-peptide: 2
  • Reconstituted Complex: 2
  • Two-hybrid: 12

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 270
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 6
  • Positive Genetic: 24
  • Synthetic Growth Defect: 32
  • Synthetic Lethality: 6
  • Synthetic Rescue: 1

Expression Summary
Length (a.a.) 1,379
Molecular Weight (Da) 157,405
Isoelectric Point (pI) 4.91
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrVII:1027370 to 1031509 | ORF Map | GBrowse
This feature contains embedded feature(s): YGR270C-A
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..4140 1027370..1031509 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003502
References cited on this page View Complete Literature Guide for YTA7
1) Schnall R, et al.  (1994) Identification of a set of yeast genes coding for a novel family of putative ATPases with high similarity to constituents of the 26S protease complex. Yeast 10(9):1141-55
2) Agostoni Carbone ML, et al.  (1998) A 9359 bp fragment from the right arm of Saccharomyces cerevisiae chromosome VII includes the FOL2 and YTA7 genes and three unknown open reading frames. Yeast 14(6):587-91
3) Ubersax JA, et al.  (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
4) Gradolatto A, et al.  (2008) Saccharomyces cerevisiae Yta7 Regulates Histone Gene Expression. Genetics 179(1):291-304
5) Fillingham J, et al.  (2009) Two-color cell array screen reveals interdependent roles for histone chaperones and a chromatin boundary regulator in histone gene repression. Mol Cell 35(3):340-51
6) Ghosh Dastidar R, et al.  (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2(1):30