Standard Name	FOL2 1, 2
Systematic Name	YGR267C
Feature Type	ORF, Verified
Description	GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway (1)
Name Description	FOLic acid synthesis

Chromosomal Location	ChrVII:1025735 to 1025004 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 215 cM

	View Computational GO annotations for FOL2
Molecular Function
Manually curated	GTP cyclohydrolase I activity (IMP)
Biological Process
Manually curated	folic acid-containing compound biosynthetic process (IMP)
Cellular Component
High-throughput	cytoplasm (IDA) nucleus (IDA)

Pathways	folate biosynthesis pathways of chorismate

Classical genetics
null	auxotrophy inviable
unspecified	auxotrophy
Large-scale survey
null	inviable resistance to sulfanilamide: decreased resistance to methotrexate: decreased
overexpression	filamentous growth: increased
reduction of function	chromosome/plasmid maintenance: abnormal competitive fitness: increased
repressible	cell cycle progression in S phase: abnormal chromosome/plasmid maintenance: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	41 total interaction(s) for 39 unique genes/features.
Physical Interactions	Affinity Capture-MS: 13 Affinity Capture-RNA: 1 Biochemical Activity: 4 Two-hybrid: 7
Genetic Interactions	Dosage Lethality: 1 Negative Genetic: 10 Positive Genetic: 4 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:1025735 to 1025004 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 215 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..732 1025735..1025004 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003499