SAY1/YGR263C Summary Help

Standard Name SAY1 1
Systematic Name YGR263C
Feature Type ORF, Verified
Description Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; active both in the endoplasmic reticulum (ER) and in lipid droplets; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the ER (1, 2, 3)
Name Description Steryl Acetyl hYdrolase 1
Chromosomal Location
ChrVII:1019241 to 1017967 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All SAY1 GO evidence and references
  View Computational GO annotations for SAY1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
30 total interaction(s) for 20 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 1
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 12
  • Positive Genetic: 10
  • Synthetic Lethality: 2
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 424
Molecular Weight (Da) 48,540
Isoelectric Point (pI) 7.46
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:1019241 to 1017967 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1275 1019241..1017967 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003495
References cited on this page View Complete Literature Guide for SAY1
1) Tiwari R, et al.  (2007) An acetylation/deacetylation cycle controls the export of sterols and steroids from S. cerevisiae. EMBO J 26(24):5109-19
2) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
3) Currie E, et al.  (2014) High-Confidence Proteomic Analysis of Yeast Lipid Droplets Identifies Additional Droplet Proteins and Reveals Connections to Dolichol Synthesis and Sterol Acetylation. J Lipid Res ()