APL6/YGR261C Summary

APL6 BASIC INFORMATION

Standard Name	APL6 1
Systematic Name	YGR261C
Alias	YKS5 2
Feature Type	ORF, Verified
Description	Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools (1, 2)
Name Description	clathrin Adaptor Protein complex Large chain 1

GO Annotations	All APL6 GO evidence and references
	View Computational GO annotations for APL6
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	Golgi to vacuole transport (IMP) vesicle-mediated transport (TAS)
Cellular Component
Manually curated	AP-3 adaptor complex (ISS)

Mutant Phenotype	All APL6 Phenotype details and references
Classical genetics
null	metal resistance: decreased Vam3p distribution: abnormal alkaline phosphatase modification: decreased
Large-scale survey
null	glycogen accumulation: increased polyphosphate accumulation: abnormal inositols excretion: increased Pho8p (ALP) modification: decreased resistance to rapamycin: increased resistance to wortmannin: normal resistance to calcium dichloride: decreased resistance to hygromycin B: decreased resistance to nickel sulfate: decreased utilization of phosphorus source: decreased viable

Interactions	APL6 All interactions details and references
	84 total interaction(s) for 45 unique genes/features.
Physical Interactions	Affinity Capture-MS: 17 Affinity Capture-Western: 4 Co-purification: 1 PCA: 3 Two-hybrid: 7
Genetic Interactions	Phenotypic Enhancement: 38 Phenotypic Suppression: 6 Synthetic Growth Defect: 4 Synthetic Lethality: 2 Synthetic Rescue: 2

Sequence Information

ChrVII:1016756 to 1014327 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2005-11-29 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2430	1016756..1014327	2005-11-29	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003493

APL6 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for APL6

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for APL6]

1)	Cowles CR, et al. (1997) The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole. Cell 91(1):109-18
2)	Panek HR, et al. (1997) Suppressors of YCK-encoded yeast casein kinase 1 deficiency define the four subunits of a novel clathrin AP-like complex. EMBO J 16(14):4194-204

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