Standard Name	APL6 1
Systematic Name	YGR261C
Alias	YKS5 2
Feature Type	ORF, Verified
Description	Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools (1, 2)
Name Description	clathrin Adaptor Protein complex Large chain 1

Chromosomal Location	ChrVII:1016750 to 1014321 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for APL6
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	Golgi to vacuole transport (IMP) protein targeting to vacuole (IMP)
Cellular Component
Manually curated	AP-3 adaptor complex (IMP)

Classical genetics
null	metal resistance: decreased Vam3p distribution: abnormal alkaline phosphatase modification: decreased
Large-scale survey
null	polyphosphate accumulation: abnormal glycogen accumulation: increased inositol excretion: increased competitive fitness: decreased haploinsufficient Pho8p (ALP) modification: decreased resistance to fenpropimorph: increased resistance to sirolimus: increased resistance to cycloheximide: decreased resistance to amitrole: decreased resistance to mycophenolic acid: increased resistance to tunicamycin: increased resistance to nickel sulfate: decreased resistance to wortmannin: normal resistance to caffeine: decreased resistance to calcium dichloride: decreased resistance to hygromycin B: decreased resistance to benzo[a]pyrene: decreased stress resistance: decreased utilization of phosphorus source: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	126 total interaction(s) for 78 unique genes/features.
Physical Interactions	Affinity Capture-MS: 21 Affinity Capture-RNA: 1 Affinity Capture-Western: 5 Co-purification: 1 PCA: 4 Two-hybrid: 7
Genetic Interactions	Negative Genetic: 64 Phenotypic Suppression: 1 Positive Genetic: 10 Synthetic Growth Defect: 7 Synthetic Lethality: 2 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:1016750 to 1014321 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2430 1016750..1014321 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003493