Standard Name	SDA1
Systematic Name	YGR245C
Feature Type	ORF, Verified
Description	Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis (1, 2, 3)
Name Description	Severe Depolymerization of Actin 1

Chromosomal Location	ChrVII:982068 to 979765 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for SDA1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	actin cytoskeleton organization (IMP) ribosomal large subunit biogenesis (IMP) ribosomal large subunit export from nucleus (IMP) traversing start control point of mitotic cell cycle (IMP)
Cellular Component
Manually curated	nucleus (IDA)

Classical genetics
conditional	actin cytoskeleton morphology: abnormal cell cycle progression in G1 phase: arrested chitin deposition: decreased cytokinesis: delayed endocytosis: decreased heat sensitivity: increased
null	inviable
overexpression	cytokinesis: delayed growth in exponential phase: decreased rate
repressible	cell cycle progression in G1 phase: arrested cytokinesis: decreased growth in exponential phase: decreased rate
Large-scale survey
null	inviable starvation resistance: decreased
reduction of function	competitive fitness: normal resistance to methyl methanesulfonate: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	185 total interaction(s) for 92 unique genes/features.
Physical Interactions	Affinity Capture-MS: 115 Affinity Capture-RNA: 2 Affinity Capture-Western: 9 Co-purification: 19 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 36 Synthetic Lethality: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:982068 to 979765 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2304 982068..979765 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003477