Standard Name	PHO81 1
Systematic Name	YGR233C
Alias	VAC6 2
Feature Type	ORF, Verified
Description	Cyclin-dependent kinase (CDK) inhibitor; regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p; relative distribution to the nucleus increases upon DNA replication stress (3, 4, 5, 6, 7) Also known as: phoS 8
Name Description	PHOsphate metabolism

Chromosomal Location	ChrVII:958210 to 954674 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for PHO81
Molecular Function
Manually curated	cyclin-dependent protein serine/threonine kinase inhibitor activity (TAS)
Biological Process
Manually curated	phosphate-containing compound metabolic process (IMP)
Cellular Component
Manually curated	nucleus (IDA)
High-throughput	cytoplasm (IDA) nucleus (IDA)

Regulatory modules	predicted: cellcycle (299)

Classical genetics
activation	vacuolar distribution: abnormal vacuolar morphology: abnormal
null	N-ribosylnicotinamide excretion: decreased resistance to disodium selenite: decreased
overexpression	bud neck morphology: abnormal cell cycle progression in G1 phase: abnormal cellular morphology: abnormal
reduction of function	acid phosphatase activity: decreased
Large-scale survey
null	alkaline pH resistance: decreased competitive fitness: decreased competitive fitness: increased dessication resistance: decreased heat sensitivity: increased viable
overexpression	vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	74 total interaction(s) for 34 unique genes/features.
Physical Interactions	Affinity Capture-MS: 25 Affinity Capture-RNA: 1 Affinity Capture-Western: 7 Biochemical Activity: 5 Reconstituted Complex: 6 Two-hybrid: 12
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 1 Negative Genetic: 5 Phenotypic Enhancement: 4 Phenotypic Suppression: 4 Synthetic Growth Defect: 2 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:958210 to 954674 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3537 958210..954674 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003465