Standard Name	NAS6 1
Systematic Name	YGR232W
Feature Type	ORF, Verified
Description	Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6 (1, 2, 3, 4, 5)
Name Description	Non-ATPase Subunit 6 1

Chromosomal Location	ChrVII:953960 to 954646 | ORF Map | GBrowse

Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	proteasome regulatory particle assembly (IGI, IMP) proteolysis (IPI, ISS)
Cellular Component
Manually curated	cytosol (IDA) nucleus (IDA) colocalizes_with proteasome regulatory particle (IDA)

Classical genetics
null	resistance to L-azetidine-2-carboxylic acid: decreased
Large-scale survey
null	competitive fitness: increased oxidative stress resistance: decreased resistance to cycloheximide: decreased resistance to streptomycin: decreased resistance to amitrole: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	155 total interaction(s) for 43 unique genes/features.
Physical Interactions	Affinity Capture-MS: 83 Affinity Capture-RNA: 3 Affinity Capture-Western: 35 Co-crystal Structure: 2 Co-purification: 1 PCA: 1 Reconstituted Complex: 1 Two-hybrid: 5
Genetic Interactions	Dosage Lethality: 1 Negative Genetic: 4 Phenotypic Enhancement: 5 Synthetic Growth Defect: 11 Synthetic Lethality: 1 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:953960 to 954646 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..687 953960..954646 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003464