AMA1/YGR225W Summary

AMA1 BASIC INFORMATION

Standard Name	AMA1 1
Systematic Name	YGR225W
Alias	SPO70
Feature Type	ORF, Verified
Description	Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis (1, 2)
Name Description	Activator of Meiotic APC/C 1

GO Annotations	All AMA1 GO evidence and references
	View Computational GO annotations for AMA1
Molecular Function
Manually curated	enzyme activator activity (IMP, IPI)
Biological Process
Manually curated	ascospore formation (IMP) ascospore wall assembly (IMP) meiosis I (IEP, IMP) protein catabolic process (IMP, IPI)
Cellular Component
Manually curated	anaphase-promoting complex (IPI)

Mutant Phenotype	All AMA1 Phenotype details and references
Classical genetics
null	glucosamine accumulation: absent meiosis: decreased Clb1p accumulation: increased Ssp1 accumulation: increased Smk1-HA modification: decreased spore wall formation: abnormal sporulation: decreased
overexpression	Clb1p accumulation: decreased
reduction of function	sporulation: decreased
Large-scale survey
null	spore wall formation: absent sporulation: absent sporulation: abnormal viable

Interactions	AMA1 All interactions details and references
	11 total interaction(s) for 10 unique genes/features.
Physical Interactions	Affinity Capture-Western: 1 Biochemical Activity: 1 Two-hybrid: 2
Genetic Interactions	Dosage Lethality: 1 Phenotypic Suppression: 4 Synthetic Lethality: 1 Synthetic Rescue: 1

Sequence Information

ChrVII:945148 to 947022 | |

Last Update

Coordinates: 2005-11-29 | Sequence: 2005-11-29

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1183	945148..946330	2004-07-20	2000-12-01
Intron	1184..1276	946331..946423	2004-07-20	2000-12-01
CDS	1277..1875	946424..947022	2005-11-29	2005-11-29

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003457

AMA1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for AMA1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for AMA1]

1)	Cooper KF, et al. (2000) Ama1p is a meiosis-specific regulator of the anaphase promoting complex/cyclosome in yeast. Proc Natl Acad Sci U S A 97(26):14548-53
2)	Coluccio A, et al. (2004) Morphogenetic pathway of spore wall assembly in Saccharomyces cerevisiae. Eukaryot Cell 3(6):1464-75

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