AMA1/YGR225W Summary Help

Standard Name AMA1 1
Systematic Name YGR225W
Alias SPO70 2
Feature Type ORF, Verified
Description Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis; prevents premature assembly of the meiosis I spindle, required for DSB induced prophase I arrest (1, 3, 4)
Name Description Activator of Meiotic APC/C 1
Chromosomal Location
ChrVII:945145 to 947019 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All AMA1 GO evidence and references
  View Computational GO annotations for AMA1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
null
overexpression
reduction of function
Large-scale survey
null
Resources
22 total interaction(s) for 20 unique genes/features.
Physical Interactions
  • Affinity Capture-Western: 4
  • Biochemical Activity: 2
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Lethality: 2
  • Negative Genetic: 4
  • Phenotypic Suppression: 6
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 593
Molecular Weight (Da) 67,026
Isoelectric Point (pI) 8.27
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:945145 to 947019 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2005-11-29
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1183 945145..946327 2011-02-03 2000-12-01
Intron 1184..1276 946328..946420 2011-02-03 2000-12-01
CDS 1277..1875 946421..947019 2011-02-03 2005-11-29
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003457
References cited on this page View Complete Literature Guide for AMA1
1) Cooper KF, et al.  (2000) Ama1p is a meiosis-specific regulator of the anaphase promoting complex/cyclosome in yeast. Proc Natl Acad Sci U S A 97(26):14548-53
2) Chu S, et al.  (1998) The transcriptional program of sporulation in budding yeast. Science 282(5389):699-705
3) Coluccio A, et al.  (2004) Morphogenetic pathway of spore wall assembly in Saccharomyces cerevisiae. Eukaryot Cell 3(6):1464-75
4) Okaz E, et al.  (2012) Meiotic prophase requires proteolysis of M phase regulators mediated by the meiosis-specific APC/CAma1. Cell 151(3):603-18