AZR1/YGR224W Summary Help

Standard Name AZR1 1
Systematic Name YGR224W
Feature Type ORF, Verified
Description Plasma membrane transporter of the major facilitator superfamily; involved in resistance to azole drugs such as ketoconazole and fluconazole (1, 2)
Name Description Acetic Acid and AZoles Resistance 1
Chromosomal Location
ChrVII:942806 to 944647 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All AZR1 GO evidence and references
  View Computational GO annotations for AZR1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 7 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
15 total interaction(s) for 15 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 1
  • PCA: 3

Genetic Interactions
  • Negative Genetic: 7
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 613
Molecular Weight (Da) 67,168
Isoelectric Point (pI) 9.58
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:942806 to 944647 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1842 942806..944647 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000003456
References cited on this page View Complete Literature Guide for AZR1
1) Tenreiro S, et al.  (2000) Expression of the AZR1 gene (ORF YGR224w), encoding a plasma membrane transporter of the major facilitator superfamily, is required for adaptation to acetic acid and resistance to azoles in Saccharomyces cerevisiae. Yeast 16(16):1469-81
2) Bauer BE, et al.  (2003) Weak organic acid stress inhibits aromatic amino acid uptake by yeast, causing a strong influence of amino acid auxotrophies on the phenotypes of membrane transporter mutants. Eur J Biochem 270(15):3189-95