CRM1/YGR218W Summary

CRM1 BASIC INFORMATION

Standard Name	CRM1 1
Systematic Name	YGR218W
Alias	KAP124 , XPO1
Feature Type	ORF, Verified
Description	Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin (2, 3)
Name Description	Chromosome Region Maintenance 1

GO Annotations	All CRM1 GO evidence and references
	View Computational GO annotations for CRM1
Molecular Function
Manually curated	protein transporter activity (IDA, IMP)
Biological Process
Manually curated	mRNA export from nucleus (IMP) protein export from nucleus (IMP) protein localization to kinetochore (IGI) ribosomal large subunit export from nucleus (IMP)
Cellular Component
Manually curated	kinetochore (IDA) nucleus (IDA) spindle pole body (IDA)

Mutant Phenotype	All CRM1 Phenotype details and references
Classical genetics
conditional	actin cytoskeleton morphology: abnormal endocytosis: decreased nuclear export: decreased Mad1p-GFP distribution: abnormal Dna2 distribution: abnormal GFP-Scd5p distribution: abnormal
unspecified	Spc72p distribution: abnormal
Large-scale survey
null	inviable

Interactions	CRM1 All interactions details and references
	158 total interaction(s) for 93 unique genes/features.
Physical Interactions	Affinity Capture-MS: 43 Affinity Capture-RNA: 1 Affinity Capture-Western: 14 Biochemical Activity: 1 Co-localization: 5 Protein-peptide: 1 Reconstituted Complex: 12 Two-hybrid: 68
Genetic Interactions	Dosage Rescue: 5 Phenotypic Enhancement: 4 Synthetic Lethality: 4

Sequence Information

ChrVII:932544 to 935798 | |

Last Update

Coordinates: 2004-07-20 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..3255	932544..935798	2004-07-20	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003450

CRM1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for CRM1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CRM1]

1)	Toda T, et al. (1992) Fission yeast pap1-dependent transcription is negatively regulated by an essential nuclear protein, crm1. Mol Cell Biol 12(12):5474-84
2)	Maurer P, et al. (2001) The nuclear export receptor Xpo1p forms distinct complexes with NES transport substrates and the yeast Ran binding protein 1 (Yrb1p). Mol Biol Cell 12(3):539-49
3)	Johnson AW, et al. (2002) Nuclear export of ribosomal subunits. Trends Biochem Sci 27(11):580-5

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