Standard Name	GPI1
Systematic Name	YGR216C
Feature Type	ORF, Verified
Description	Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs (1, 2, 3, 4)
Name Description	GlycosylPhosphatidylInositol anchoring biosynthesis 2, 3

Chromosomal Location	ChrVII:924462 to 922633 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for GPI1
Molecular Function
Manually curated	contributes_to phosphatidylinositol N-acetylglucosaminyltransferase activity (IC)
Biological Process
Manually curated	GPI anchor biosynthetic process (IDA, IMP)
Cellular Component
Manually curated	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex (IGI, ISA) integral to membrane (ISM)
High-throughput	integral to membrane (ISM)

Classical genetics
null	invasive growth: increased resistance to hygromycin B: decreased resistance to trisodium vanadate: decreased resistance to staurosporine: decreased
Large-scale survey
null	inviable resistance to sulfanilamide: decreased starvation resistance: decreased
repressible	protein transport: abnormal
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	60 total interaction(s) for 60 unique genes/features.
Physical Interactions	PCA: 3
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 47 Phenotypic Suppression: 1 Positive Genetic: 3 Synthetic Lethality: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:924462 to 922633 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1830 924462..922633 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003448