SER2/YGR208W Summary

SER2 BASIC INFORMATION

Standard Name	SER2 1
Systematic Name	YGR208W
Feature Type	ORF, Verified
Description	Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source (2, 3)
Name Description	SERine requiring 2

GO Annotations	All SER2 GO evidence and references
	View Computational GO annotations for SER2
Molecular Function
Manually curated	phosphoserine phosphatase activity (IMP)
Biological Process
Manually curated	L-serine biosynthetic process (IMP)
Cellular Component
High-throughput	cytoplasm (IDA) nucleus (IDA)

Pathways	serine biosynthesis from 3-phosphoglycerate superpathway of serine and glycine biosynthesis

Mutant Phenotype	All SER2 Phenotype details and references
Large-scale survey
null	competitive fitness: decreased hyperosmotic stress resistance: decreased resistance to rapamycin: decreased resistance to mycophenolic acid: decreased resistance to amiodarone: decreased resistance to doxorubicin: decreased toxin resistance: decreased utilization of nitrogen source: absent viable

Interactions	SER2 All interactions details and references
	View additional details at BioGRID
	159 total interaction(s) for 122 unique genes/features.
Physical Interactions	Affinity Capture-Western: 3
Genetic Interactions	Negative Genetic: 132 Positive Genetic: 10 Synthetic Growth Defect: 6 Synthetic Lethality: 8

Sequence Information

ChrVII:911888 to 912817 | |

Genetic position: 168 cM

Last Update

Coordinates: 2004-07-20 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..930	911888..912817	2004-07-20	1996-07-31

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003440

SER2 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for SER2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SER2]

1)	Song, J.M., et al. (1995) Identification and characterization of the Saccharomyces cerevisiae SER2 Gene. Unpublished
2)	Melcher K and Entian KD (1992) Genetic analysis of serine biosynthesis and glucose repression in yeast. Curr Genet 21(4-5):295-300
3)	Albers E, et al. (2003) Ser3p (Yer081wp) and Ser33p (Yil074cp) are phosphoglycerate dehydrogenases in Saccharomyces cerevisiae. J Biol Chem 278(12):10264-72

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.