OKP1/YGR179C Summary

OKP1 BASIC INFORMATION

Standard Name	OKP1
Systematic Name	YGR179C
Feature Type	ORF, Verified
Description	Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly (1, 2)
Name Description	Outer Kinetochore Protein 1

GO Annotations	All OKP1 GO evidence and references
	View Computational GO annotations for OKP1
Molecular Function
Manually curated	protein binding (IDA)
Biological Process
Manually curated	attachment of spindle microtubules to kinetochore (IMP) chromosome segregation (IPI)
Cellular Component
Manually curated	COMA complex (IDA) condensed nuclear chromosome kinetochore (IDA)

Mutant Phenotype	All OKP1 Phenotype details and references
Classical genetics
conditional	cell cycle progression in anaphase: absent heat sensitivity: increased
Large-scale survey
null	inviable

Interactions	OKP1 All interactions details and references
	83 total interaction(s) for 36 unique genes/features.
Physical Interactions	Affinity Capture-MS: 31 Affinity Capture-Western: 17 Biochemical Activity: 1 Co-fractionation: 2 Co-localization: 2 Reconstituted Complex: 1 Two-hybrid: 12
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 2 Synthetic Growth Defect: 7 Synthetic Lethality: 7

Sequence Information

ChrVII:854900 to 853680 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-07-20 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1221	854900..853680	2004-07-20	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003411

OKP1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for OKP1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for OKP1]

1)	Ortiz J, et al. (1999) A putative protein complex consisting of Ctf19, Mcm21, and Okp1 represents a missing link in the budding yeast kinetochore. Genes Dev 13(9):1140-55
2)	De Wulf P, et al. (2003) Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes. Genes Dev 17(23):2902-21

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