PSD2/YGR170W Summary Help

Standard Name PSD2
Systematic Name YGR170W
Feature Type ORF, Verified
Description Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes; converts phosphatidylserine to phosphatidylethanolamine; controls vacuolar membrane phospholipid content by regulating phospholipids in compartments that will eventually give rise to the vacuole; loss of Psd2p causes a specific reduction in vacuolar membrane PE levels while total PE levels are not significantly affected (1, 2, 3, 4, 5)
Chromosomal Location
ChrVII:837142 to 840558 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All PSD2 GO evidence and references
  View Computational GO annotations for PSD2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Resources
Pathways
Classical genetics
null
Large-scale survey
null
Resources
185 total interaction(s) for 113 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 10
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 1
  • Co-purification: 1
  • PCA: 1
  • Reconstituted Complex: 2

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 119
  • Phenotypic Enhancement: 25
  • Positive Genetic: 6
  • Synthetic Growth Defect: 12
  • Synthetic Lethality: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,138
Molecular Weight (Da) 130,064
Isoelectric Point (pI) 7.85
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:837142 to 840558 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3417 837142..840558 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003402
References cited on this page View Complete Literature Guide for PSD2
1) Trotter PJ and Voelker DR  (1995) Identification of a non-mitochondrial phosphatidylserine decarboxylase activity (PSD2) in the yeast Saccharomyces cerevisiae. J Biol Chem 270(11):6062-70
2) Carson MA, et al.  (1984) Coordinate regulation of phosphatidylserine decarboxylase activity and phospholipid N-methylation in yeast. J Biol Chem 259(10):6267-73
3) Voelker DR  (1997) Phosphatidylserine decarboxylase. Biochim Biophys Acta 1348(1-2):236-44
4) Storey MK, et al.  (2001) Phosphatidylethanolamine has an essential role in Saccharomyces cerevisiae that is independent of its ability to form hexagonal phase structures. J Biol Chem 276(51):48539-48
5) Gulshan K, et al.  (2010) Compartment-specific Synthesis of Phosphatidylethanolamine Is Required for Normal Heavy Metal Resistance. Mol Biol Cell 21(3):443-55