TIF4631/YGR162W Summary Help

TIF4631 BASIC INFORMATION

Standard Name TIF4631 1, 2
Systematic Name YGR162W
Feature Type ORF, Verified
Description Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); homologous to Tif4632p (1, 3, 4)
Name Description Translation Initiation Factor 1, 2
Gene Product Alias eiF4G1 5
GO Annotations All TIF4631 GO evidence and references
    View Computational GO annotations for TIF4631
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All TIF4631 Phenotype details and references
Classical genetics
conditional
null
Large-scale survey
null
Interactions TIF4631 All interactions details and references
190 total interaction(s) for 105 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 108
  • Affinity Capture-Western: 11
  • Co-crystal Structure: 2
  • Far Western: 1
  • Reconstituted Complex: 17
  • Two-hybrid: 1
Genetic Interactions
  • Dosage Rescue: 2
  • Phenotypic Enhancement: 14
  • Phenotypic Suppression: 21
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 8
  • Synthetic Rescue: 1
Sequence Information
ChrVII:824064 to 826922 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2004-07-20 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2859 824064..826922 2004-07-20 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003394

TIF4631 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for TIF4631

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for TIF4631]

1) Goyer C, et al.  (1993) TIF4631 and TIF4632: two yeast genes encoding the high-molecular-weight subunits of the cap-binding protein complex (eukaryotic initiation factor 4F) contain an RNA recognition motif-like sequence and carry out an essential function. Mol Cell Biol 13(8):4860-74
2) Lanker S, et al.  (1992) Interactions of the eIF-4F subunits in the yeast Saccharomyces cerevisiae. J Biol Chem 267(29):21167-71
3) Tarun SZ Jr, et al.  (1997) Translation initiation factor eIF4G mediates in vitro poly(A) tail-dependent translation. Proc Natl Acad Sci U S A 94(17):9046-51
4) Dominguez D, et al.  (1999) Interaction of translation initiation factor eIF4G with eIF4A in the yeast Saccharomyces cerevisiae. J Biol Chem 274(38):26720-6
5) Neff CL and Sachs AB  (1999) Eukaryotic translation initiation factors 4G and 4A from Saccharomyces cerevisiae interact physically and functionally. Mol Cell Biol 19(8):5557-64