CAF130/YGR134W Summary

CAF130 BASIC INFORMATION

Standard Name	CAF130 1
Systematic Name	YGR134W
Feature Type	ORF, Verified
Description	Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation (1)
Name Description	CCR4 Associated Factor 1

GO Annotations	All CAF130 GO evidence and references
	View Computational GO annotations for CAF130
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	regulation of transcription from RNA polymerase II promoter (IPI)
Cellular Component
Manually curated	CCR4-NOT core complex (IPI)

Mutant Phenotype	All CAF130 Phenotype details and references
Classical genetics
null	resistance to hydroxyurea: normal viable
Large-scale survey
null	heat sensitivity: increased viable

Interactions	CAF130 All interactions details and references
	76 total interaction(s) for 45 unique genes/features.
Physical Interactions	Affinity Capture-MS: 24 Affinity Capture-RNA: 1 Affinity Capture-Western: 10 Co-purification: 1 Two-hybrid: 5
Genetic Interactions	Phenotypic Enhancement: 21 Phenotypic Suppression: 7 Synthetic Growth Defect: 3 Synthetic Lethality: 4

Sequence Information

ChrVII:757775 to 761143 | |

Last Update

Coordinates: 2004-07-20 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..3369	757775..761143	2004-07-20	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003366

CAF130 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for CAF130

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CAF130]

1)	Chen J, et al. (2001) Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex. J Mol Biol 314(4):683-94

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