Standard Name	PEX4 1
Systematic Name	YGR133W
Alias	PAS2 2 , UBC10 3
Feature Type	ORF, Verified
Description	Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis (2, 3, 4, 5)
Name Description	PEroXin 1

Chromosomal Location	ChrVII:756896 to 757447 | ORF Map | GBrowse

	View Computational GO annotations for PEX4
Molecular Function
Manually curated	ubiquitin-protein ligase activity (IDA, ISS)
Biological Process
Manually curated	peroxisome organization (IMP) protein autoubiquitination (IDA) protein import into peroxisome matrix, receptor recycling (IMP) protein monoubiquitination (IDA, IMP) protein polyubiquitination (TAS)
Cellular Component
Manually curated	peroxisome (IDA)

Classical genetics
null	Pex5p modification: increased
reduction of function	peroxisomal morphology: absent peroxisomal transport: absent utilization of carbon source: absent
Large-scale survey
null	competitive fitness: decreased haploproficient heat sensitivity: increased resistance to oleate: decreased resistance to chloroquine: decreased resistance to BPS: decreased resistance to ethanol: decreased resistance to sodium arsenite: decreased stress resistance: decreased vacuolar morphology: abnormal vegetative growth: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	86 total interaction(s) for 65 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 Affinity Capture-Western: 3 Biochemical Activity: 1 Co-crystal Structure: 1 PCA: 5 Two-hybrid: 2
Genetic Interactions	Negative Genetic: 57 Phenotypic Enhancement: 1 Positive Genetic: 3 Synthetic Growth Defect: 7 Synthetic Lethality: 4 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:756896 to 757447 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..552 756896..757447 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003365