PHB1/YGR132C Summary

PHB1 BASIC INFORMATION

Standard Name	PHB1
Systematic Name	YGR132C
Feature Type	ORF, Verified
Description	Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation (1, 2, 3, 4, 5)
Name Description	ProHiBitin

GO Annotations	All PHB1 GO evidence and references
	View Computational GO annotations for PHB1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	inner mitochondrial membrane organization (IGI, IMP) mitochondrion inheritance (IMP) mitochondrion morphogenesis (IMP) negative regulation of proteolysis (IMP, IPI) protein folding (IDA, IPI, ISS) replicative cell aging (IMP)
Cellular Component
Manually curated	mitochondrial inner membrane (IDA) mitochondrion (IDA)
High-throughput	mitochondrion (IDA)

Mutant Phenotype	All PHB1 Phenotype details and references
Classical genetics
null	lifespan: decreased mitochondrial morphology: abnormal mitochondrial rho- mutation frequency: increased replicative lifespan: decreased viable
repressible	mitochondrial morphology: abnormal mitochondrial inner membrane and matrix proteins accumulation: decreased
Large-scale survey
null	mitochondrial genome maintenance: abnormal petite-negative resistance to oleate: decreased resistance to methyl methanesulfonate: decreased viable

Interactions	PHB1 All interactions details and references
	70 total interaction(s) for 53 unique genes/features.
Physical Interactions	Affinity Capture-MS: 14 Affinity Capture-Western: 5 PCA: 1
Genetic Interactions	Dosage Rescue: 2 Phenotypic Enhancement: 1 Synthetic Growth Defect: 19 Synthetic Lethality: 22 Synthetic Rescue: 6

Sequence Information

ChrVII:756457 to 755594 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-07-20 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..864	756457..755594	2004-07-20	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003364

PHB1 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for PHB1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PHB1]

1)	Coates PJ, et al. (1997) The prohibitin family of mitochondrial proteins regulate replicative lifespan. Curr Biol 7(8):607-10
2)	Berger KH and Yaffe MP (1998) Prohibitin family members interact genetically with mitochondrial inheritance components in Saccharomyces cerevisiae. Mol Cell Biol 18(7):4043-52
3)	Nijtmans LG, et al. (2000) Prohibitins act as a membrane-bound chaperone for the stabilization of mitochondrial proteins. EMBO J 19(11):2444-51
4)	Piper PW, et al. (2002) The shortened replicative life span of prohibitin mutants of yeast appears to be due to defective mitochondrial segregation in old mother cells. Aging Cell 1(2):149-57
5)	Tatsuta T, et al. (2005) Formation of membrane-bound ring complexes by prohibitins in mitochondria. Mol Biol Cell 16(1):248-59

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