Standard Name	PHB1
Systematic Name	YGR132C
Feature Type	ORF, Verified
Description	Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation (1, 2, 3, 4, 5)
Name Description	ProHiBitin

Chromosomal Location	ChrVII:756452 to 755589 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for PHB1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	inner mitochondrial membrane organization (IGI, IMP) mitochondrion inheritance (IMP) mitochondrion morphogenesis (IMP) negative regulation of proteolysis (IMP, IPI) protein folding (IDA, IPI, ISS) replicative cell aging (IMP)
Cellular Component
Manually curated	mitochondrial inner membrane (IDA) mitochondrion (IDA)
High-throughput	mitochondrion (IDA)

Classical genetics
null	freeze-thaw resistance: decreased lifespan: decreased mitochondrial morphology: abnormal mitochondrial rho- mutation frequency: increased replicative lifespan: decreased viable
repressible	mitochondrial morphology: abnormal mitochondrial inner membrane and matrix proteins accumulation: decreased
Large-scale survey
null	competitive fitness: decreased mitochondrial genome maintenance: abnormal petite-negative resistance to CTBT: decreased resistance to oleate: decreased resistance to amitrole: decreased resistance to cycloheximide: decreased resistance to methyl methanesulfonate: decreased vacuolar morphology: abnormal viable
overexpression	cell cycle progression: abnormal vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	210 total interaction(s) for 135 unique genes/features.
Physical Interactions	Affinity Capture-MS: 21 Affinity Capture-Western: 7 Co-fractionation: 1 PCA: 1
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 2 Negative Genetic: 90 Phenotypic Enhancement: 1 Positive Genetic: 26 Synthetic Growth Defect: 30 Synthetic Lethality: 24 Synthetic Rescue: 6
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:756452 to 755589 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..864 756452..755589 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003364