MEP1/YGR121C Summary Help

Standard Name MEP1
Systematic Name YGR121C
Alias AMT1
Feature Type ORF, Verified
Description Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation; MEP1 has a paralog, MEP3, that arose from the whole genome duplication (1, 2, 3)
Chromosomal Location
ChrVII:732927 to 731449 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All MEP1 GO evidence and references
  View Computational GO annotations for MEP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
68 total interaction(s) for 56 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 2
  • Biochemical Activity: 1
  • Co-purification: 1
  • PCA: 11
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Rescue: 17
  • Negative Genetic: 23
  • Phenotypic Suppression: 1
  • Positive Genetic: 1
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 492
Molecular Weight (Da) 54,202
Isoelectric Point (pI) 5.33
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:732927 to 731449 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1479 732927..731449 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000003353
References cited on this page View Complete Literature Guide for MEP1
1) Marini AM, et al.  (1997) A family of ammonium transporters in Saccharomyces cerevisiae. Mol Cell Biol 17(8):4282-93
2) Marini AM, et al.  (1994) Cloning and expression of the MEP1 gene encoding an ammonium transporter in Saccharomyces cerevisiae. EMBO J 13(15):3456-63
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61