VMA21/YGR105W Summary Help

VMA21 BASIC INFORMATION

Standard Name VMA21
Systematic Name YGR105W
Feature Type ORF, Verified
Description Integral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER) (1, 2, 3, 4)
GO Annotations All VMA21 GO evidence and references
    View Computational GO annotations for VMA21
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All VMA21 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions VMA21 All interactions details and references
  View additional details at BioGRID
147 total interaction(s) for 97 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 11
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 6
  • PCA: 11
Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 78
  • Positive Genetic: 28
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 7
Sequence Information
ChrVII:698603 to 698836 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2004-07-20 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..234 698603..698836 2004-07-20 1996-07-31
Post-translational Modifications PhosphoGRID | PhosphoPep Database
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003337

VMA21 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
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  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for VMA21

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for VMA21]

1) Hill KJ and Stevens TH  (1994) Vma21p is a yeast membrane protein retained in the endoplasmic reticulum by a di-lysine motif and is required for the assembly of the vacuolar H(+)-ATPase complex. Mol Biol Cell 5(9):1039-50
2) Hirata R, et al.  (1993) VMA12 is essential for assembly of the vacuolar H(+)-ATPase subunits onto the vacuolar membrane in Saccharomyces cerevisiae. J Biol Chem 268(2):961-7
3) Graham LA and Stevens TH  (1999) Assembly of the yeast vacuolar proton-translocating ATPase. J Bioenerg Biomembr 31(1):39-47
4) Stevens TH and Forgac M  (1997) Structure, function and regulation of the vacuolar (H+)-ATPase. Annu Rev Cell Dev Biol 13:779-808