Standard Name	PCP1 1
Systematic Name	YGR101W
Alias	MDM37 , RBD1 2
Feature Type	ORF, Verified
Description	Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases (1, 2, 3, 4)
Name Description	Processing of Cytochrome c Peroxidase 1

Chromosomal Location	ChrVII:693363 to 694403 | ORF Map | GBrowse

	View Computational GO annotations for PCP1
Molecular Function
Manually curated	serine-type endopeptidase activity (IMP)
Biological Process
Manually curated	regulation of mitochondrion organization (IMP) signal peptide processing (IMP)
Cellular Component
Manually curated	mitochondrial inner membrane (IDA)
High-throughput	integral to membrane (ISM)

Classical genetics
null	cold sensitivity: increased osmotic stress resistance: decreased pro-CPY accumulation: increased Mgm1p modification: abnormal resistance to caffeine: decreased resistance to sirolimus: decreased resistance to manganese(2+): decreased vacuolar morphology: abnormal
Large-scale survey
null	glycogen accumulation: decreased competitive fitness: decreased dessication resistance: decreased endocytosis: decreased heat sensitivity: increased hyperosmotic stress resistance: decreased metal resistance: decreased mitochondrial morphology: abnormal resistance to trichothecene: increased resistance to hygromycin B: decreased resistance to farnesol: decreased resistance to CTBT: decreased resistance to arsenite(3-): decreased resistance to pyocyanin: increased respiratory growth: absent respiratory growth: decreased rate stress resistance: increased telomere length: decreased utilization of carbon source: decreased vacuolar morphology: abnormal viable
overexpression	cell cycle progression: abnormal vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	111 total interaction(s) for 107 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 Biochemical Activity: 2 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 84 Phenotypic Enhancement: 1 Positive Genetic: 19 Synthetic Growth Defect: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:693363 to 694403 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1041 693363..694403 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003333