Standard Name	ASK10 1
Systematic Name	YGR097W
Alias	RGC2 2
Feature Type	ORF, Verified
Description	Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication (2, 3, 4)
Name Description	Activator of SKn7 1

Chromosomal Location	ChrVII:678695 to 682135 | ORF Map | GBrowse

	View Computational GO annotations for ASK10
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	cellular protein catabolic process (IMP) cellular response to oxidative stress (IGI, IMP) positive regulation of glycerol transport (IMP) positive regulation of transcription from RNA polymerase II promoter (IGI, IMP)
Cellular Component
Manually curated	cytoplasm (IDA) DNA-directed RNA polymerase II, holoenzyme (IDA)
High-throughput	cytoplasm (IDA)

Regulatory modules	predicted: cellcycle (251)
Resources	YeTFaSCo

Classical genetics
null	resistance to arsenite(3-): increased
Large-scale survey
null	competitive fitness: decreased hyperosmotic stress resistance: decreased resistance to cycloheximide: decreased resistance to benomyl: decreased resistance to hydroxyurea: increased resistance to camptothecin: increased resistance to sodium arsenite: increased resistance to arsenite(3-): increased resistance to fluconazole: decreased resistance to methyl methanesulfonate: decreased resistance to tunicamycin: decreased resistance to glycolaldehyde: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	205 total interaction(s) for 195 unique genes/features.
Physical Interactions	Affinity Capture-MS: 29 Affinity Capture-RNA: 3 Affinity Capture-Western: 3 Protein-RNA: 1 Two-hybrid: 5
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 52 Phenotypic Enhancement: 1 Positive Genetic: 106 Synthetic Growth Defect: 2 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:678695 to 682135 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3441 678695..682135 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003329