TWF1/YGR080W Summary

TWF1 BASIC INFORMATION

Standard Name	TWF1 1
Systematic Name	YGR080W
Feature Type	ORF, Verified
Description	Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly (1, 2)
Name Description	TWinFilin 1
Gene Product Alias	twinfilin 1

GO Annotations	All TWF1 GO evidence and references
	View Computational GO annotations for TWF1
Molecular Function
Manually curated	actin monomer binding (IDA)
Biological Process
Manually curated	actin polymerization or depolymerization (TAS) bipolar cellular bud site selection (TAS) sequestering of actin monomers (IDA)
Cellular Component
Manually curated	actin cortical patch (TAS)
High-throughput	mating projection tip (IDA)

Mutant Phenotype	All TWF1 Phenotype details and references
Large-scale survey
null	mitochondrial genome maintenance: abnormal viable

Interactions	TWF1 All interactions details and references
	19 total interaction(s) for 14 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Co-fractionation: 1 Co-localization: 1 PCA: 2 Reconstituted Complex: 5
Genetic Interactions	Phenotypic Enhancement: 5 Phenotypic Suppression: 2 Synthetic Lethality: 1

Sequence Information

ChrVII:642014 to 643012 | |

Last Update

Coordinates: 2004-07-20 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..999	642014..643012	2004-07-20	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003312

TWF1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for TWF1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for TWF1]

1)	Goode BL, et al. (1998) Regulation of the cortical actin cytoskeleton in budding yeast by twinfilin, a ubiquitous actin monomer-sequestering protein. J Cell Biol 142(3):723-33
2)	Palmgren S, et al. (2001) Interactions with PIP2, ADP-actin monomers, and capping protein regulate the activity and localization of yeast twinfilin. J Cell Biol 155(2):251-60

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