Standard Name	PEX8 1, 2
Systematic Name	YGR077C
Alias	PAS6
Feature Type	ORF, Verified
Description	Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p (1, 3, 4)
Name Description	PEroXin 2

Chromosomal Location	ChrVII:639513 to 637744 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for PEX8
Molecular Function
Manually curated	protein binding, bridging (IDA)
Biological Process
Manually curated	protein import into peroxisome matrix (IMP)
Cellular Component
Manually curated	extrinsic to intraperoxisomal membrane (IDA)

Classical genetics
null	peroxisomal morphology: absent peroxisomal transport: decreased Pex5p accumulation: increased utilization of carbon source: absent
reduction of function	peroxisomal morphology: absent peroxisomal transport: decreased
Large-scale survey
null	competitive fitness: decreased dessication resistance: decreased heat sensitivity: increased resistance to oleate: decreased resistance to propolis extract: decreased resistance to ethanol: decreased resistance to BPS: decreased resistance to sodium arsenite: decreased stress resistance: decreased toxin resistance: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	74 total interaction(s) for 63 unique genes/features.
Physical Interactions	Affinity Capture-MS: 9 Affinity Capture-RNA: 1 Affinity Capture-Western: 3 Co-fractionation: 3 PCA: 1 Protein-RNA: 1 Reconstituted Complex: 1 Two-hybrid: 7
Genetic Interactions	Dosage Lethality: 2 Negative Genetic: 37 Synthetic Growth Defect: 8 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:639513 to 637744 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1770 639513..637744 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003309