SPT4/YGR063C Summary Help

SPT4 BASIC INFORMATION

Standard Name SPT4 1
Systematic Name YGR063C
Feature Type ORF, Verified
Description Protein involved in the regulating Pol I and Pol II transcription, pre-mRNA processing, kinetochore function, and gene silencing; forms a complex with Spt5p (2, 3, 4, 5)
Name Description SuPpressor of Ty
GO Annotations All SPT4 GO evidence and references
    View Computational GO annotations for SPT4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All SPT4 Phenotype details and references
Classical genetics
null
reduction of function
unspecified
Large-scale survey
null
Interactions SPT4 All interactions details and references
211 total interaction(s) for 153 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 46
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 6
  • Biochemical Activity: 1
  • Co-crystal Structure: 1
  • Two-hybrid: 2
Genetic Interactions
  • Dosage Rescue: 4
  • Phenotypic Enhancement: 69
  • Phenotypic Suppression: 14
  • Synthetic Growth Defect: 20
  • Synthetic Lethality: 41
  • Synthetic Rescue: 5
Sequence Information
ChrVII:617828 to 617520 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: 40 cM
Last Update Coordinates: 2004-07-20 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..309 617828..617520 2004-07-20 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003295

SPT4 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for SPT4

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SPT4]

1) Fassler, J. and Winston, F.  (1989) Personal Communication, Mortimer Map Edition 10
2) Yamaguchi Y, et al.  (2001) SPT genes: key players in the regulation of transcription, chromatin structure and other cellular processes. J Biochem 129(2):185-91
3) Lindstrom DL, et al.  (2003) Dual roles for Spt5 in pre-mRNA processing and transcription elongation revealed by identification of Spt5-associated proteins. Mol Cell Biol 23(4):1368-78
4) Rondon AG, et al.  (2003) Molecular evidence for a positive role of Spt4 in transcription elongation. EMBO J 22(3):612-20
5) Schneider DA, et al.  (2006) RNA polymerase II elongation factors Spt4p and Spt5p play roles in transcription elongation by RNA polymerase I and rRNA processing. Proc Natl Acad Sci U S A 103(34):12707-12