COX18/YGR062C Summary Help

Standard Name COX18
Systematic Name YGR062C
Alias OXA2
Feature Type ORF, Verified
Description Protein required for membrane insertion of C-terminus of Cox2p; mitochondrial integral inner membrane protein; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC (1, 2, 3, 4, 5 and see Summary Paragraph)
Name Description Cytochrome c OXidase
Chromosomal Location
ChrVII:617278 to 616328 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All COX18 GO evidence and references
  View Computational GO annotations for COX18
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 5 genes
Classical genetics
Large-scale survey
15 total interaction(s) for 12 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 5

Genetic Interactions
  • Dosage Rescue: 2
  • Phenotypic Suppression: 1
  • Synthetic Lethality: 2
  • Synthetic Rescue: 2

Expression Summary
Length (a.a.) 316
Molecular Weight (Da) 35,650
Isoelectric Point (pI) 11.85
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrVII:617278 to 616328 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..951 617278..616328 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003294

COX18 encodes a protein required for the export of the C-terminal domain of Cox2p from the mitochondrial matrix into the intermembrane space, a crucial step in the assembly of cytochrome c oxidase (2). Cox18p interacts physically with Pnt1p and Mss2p, which are also involved in export of the Cox2p C terminus (2). Cox18p is an integral protein of the mitochondrial inner membrane, with domains exposed on each face of the membrane (1, 2). The cox18 null mutation eliminates cytochrome c oxidase activity and blocks respiratory growth (1, 2).

Last updated: 2002-06-12 Contact SGD

References cited on this page View Complete Literature Guide for COX18
1) Souza RL, et al.  (2000) Cloning and characterization of COX18, a Saccharomyces cerevisiae PET gene required for the assembly of cytochrome oxidase. J Biol Chem 275(20):14898-902
2) Saracco SA and Fox TD  (2002) Cox18p is required for export of the mitochondrially encoded Saccharomyces cerevisiae Cox2p C-tail and interacts with Pnt1p and Mss2p in the inner membrane. Mol Biol Cell 13(4):1122-31
3) Fiumera HL, et al.  (2007) Translocation of mitochondrially synthesized Cox2 domains from the matrix to the intermembrane space. Mol Cell Biol 27(13):4664-73
4) van Bloois E, et al.  (2007) Saccharomyces cerevisiae Cox18 complements the essential Sec-independent function of Escherichia coli YidC. FEBS J 274(21):5704-13
5) Fiumera HL, et al.  (2009) Translocation and Assembly of Mitochondrially Coded Saccharomyces cerevisiae Cytochrome c Oxidase Subunit Cox2 by Oxa1 and Yme1 in the Absence of Cox18. Genetics 182(2):519-28