RSC1/YGR056W Summary

RSC1 BASIC INFORMATION

Standard Name	RSC1
Systematic Name	YGR056W
Feature Type	ORF, Verified
Description	Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook (1, 2, 3)
Name Description	Remodel the Structure of Chromatin

GO Annotations	All RSC1 GO evidence and references
	View Computational GO annotations for RSC1
Molecular Function
Manually curated	contributes_to DNA-dependent ATPase activity (IC, ISS)
Biological Process
Manually curated	ATP-dependent chromatin remodeling (IC, ISS) double-strand break repair via nonhomologous end joining (IPI) nucleosome disassembly (IDA) regulation of sporulation resulting in formation of a cellular spore (IMP) RNA elongation from RNA polymerase II promoter (IDA)
Cellular Component
Manually curated	RSC complex (IDA)

Mutant Phenotype	All RSC1 Phenotype details and references
Classical genetics
null	resistance to 6-azauracil: decreased
Large-scale survey
null	bud morphology: abnormal cell size: increased competitive fitness: decreased fermentative growth: decreased rate hyperosmotic stress resistance: decreased resistance to rapamycin: increased resistance to wortmannin: normal resistance to caffeine: decreased resistance to cycloheximide: decreased resistance to ethanol: decreased resistance to hygromycin B: decreased transposable element transposition: increased viable
overexpression	vegetative growth: decreased

Interactions	RSC1 All interactions details and references
	210 total interaction(s) for 144 unique genes/features.
Physical Interactions	Affinity Capture-MS: 49 Affinity Capture-RNA: 2 Affinity Capture-Western: 10 Co-purification: 10 Two-hybrid: 4
Genetic Interactions	Dosage Rescue: 2 Phenotypic Enhancement: 60 Phenotypic Suppression: 22 Synthetic Growth Defect: 29 Synthetic Lethality: 21 Synthetic Rescue: 1

Sequence Information

ChrVII:601665 to 604451 | |

Last Update

Coordinates: 2004-07-20 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2787	601665..604451	2004-07-20	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003288

RSC1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for RSC1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RSC1]

1)	Lorch Y, et al. (1998) Activated RSC-nucleosome complex and persistently altered form of the nucleosome. Cell 94(1):29-34
2)	Neely KE and Workman JL (2002) The complexity of chromatin remodeling and its links to cancer. Biochim Biophys Acta 1603(1):19-29
3)	Bungard D, et al. (2004) RSC1 and RSC2 are required for expression of mid-late sporulation-specific genes in Saccharomyces cerevisiae. Eukaryot Cell 3(4):910-8

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