TFC4/YGR047C Summary Help

Standard Name TFC4 1
Systematic Name YGR047C
Alias PCF1 2
Feature Type ORF, Verified
Description Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102 (1, 3, 4)
Name Description Transcription Factor class C 1
Gene Product Alias tau 131 1
Chromosomal Location
ChrVII:589469 to 586392 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All TFC4 GO evidence and references
  View Computational GO annotations for TFC4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 6 genes
Resources
Classical genetics
gain of function
null
Large-scale survey
null
Resources
81 total interaction(s) for 33 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 25
  • Affinity Capture-Western: 14
  • Co-fractionation: 1
  • Far Western: 2
  • Reconstituted Complex: 12
  • Two-hybrid: 14

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 10
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,025
Molecular Weight (Da) 120,227
Isoelectric Point (pI) 5
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:589469 to 586392 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3078 589469..586392 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003279
References cited on this page View Complete Literature Guide for TFC4
1) Marck C, et al.  (1993) The TFIIIB-assembling subunit of yeast transcription factor TFIIIC has both tetratricopeptide repeats and basic helix-loop-helix motifs. Proc Natl Acad Sci U S A 90(9):4027-31
2) Willis I, et al.  (1989) A selection for mutants of the RNA polymerase III transcription apparatus: PCF1 stimulates transcription of tRNA and 5S RNA genes. EMBO J 8(13):4281-8
3) Bartholomew B, et al.  (1991) Two components of Saccharomyces cerevisiae transcription factor IIIB (TFIIIB) are stereospecifically located upstream of a tRNA gene and interact with the second-largest subunit of TFIIIC. Mol Cell Biol 11(10):5181-9
4) Geiduschek EP and Kassavetis GA  (2001) The RNA polymerase III transcription apparatus. J Mol Biol 310(1):1-26