Standard Name	TFC4 1
Systematic Name	YGR047C
Alias	PCF1 2
Feature Type	ORF, Verified
Description	One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102 (1, 3, 4)
Name Description	Transcription Factor class C 1
Gene Product Alias	tau 131 1

Chromosomal Location	ChrVII:589469 to 586392 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for TFC4
Molecular Function
Manually curated	contributes_to DNA binding, bending (IDA) contributes_to RNA polymerase III type 1 promoter sequence-specific DNA binding (IDA) contributes_to RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity (IDA) contributes_to RNA polymerase III type 2 promoter sequence-specific DNA binding (IDA) contributes_to RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity (IDA)
Biological Process
Manually curated	5S class rRNA transcription from RNA polymerase III type 1 promoter (IDA) transcription from a RNA polymerase III hybrid type promoter (IDA) transcription from RNA polymerase III type 2 promoter (IDA, IMP)
Cellular Component
Manually curated	transcription factor TFIIIC complex (IDA)
High-throughput	cytoplasm (IDA) nucleus (IDA)

Classical genetics
gain of function	tRNA accumulation: increased
null	inviable
Large-scale survey
null	inviable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	78 total interaction(s) for 31 unique genes/features.
Physical Interactions	Affinity Capture-MS: 22 Affinity Capture-Western: 14 Co-fractionation: 1 Far Western: 2 Reconstituted Complex: 12 Two-hybrid: 14
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 10 Synthetic Lethality: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:589469 to 586392 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3078 589469..586392 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003279