Standard Name	RME1 1
Systematic Name	YGR044C
Alias	CSP1
Feature Type	ORF, Verified
Description	Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress (2, 3, 4)
Name Description	Regulator of MEiosis 1

Chromosomal Location	ChrVII:583892 to 582990 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 14 cM

	View Computational GO annotations for RME1
Molecular Function
Manually curated	RNA polymerase II core promoter proximal region sequence-specific DNA binding (IDA) sequence-specific DNA binding RNA polymerase II transcription factor activity (IMP)
Biological Process
Manually curated	negative regulation of meiosis (IMP) negative regulation of transcription during meiosis (IMP) negative regulation of transcription from RNA polymerase II promoter (IDA) positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter (IDA) positive regulation of transcription from RNA polymerase II promoter (IDA, IMP) positive regulation of transcription involved in G1/S phase of mitotic cell cycle (IDA)
Cellular Component
Manually curated	nucleus (IDA)
High-throughput	cytoplasm (IDA) nucleus (IDA)

Regulatory modules	predicted: stressResponse (637) predicted: cellcycle (275, 215) predicted: stressResponse (637) predicted: cellcycle (275, 215)
Resources	ScerTF | YEASTRACT | YeTFaSCo

Classical genetics
null	invasive growth: decreased vegetative growth: decreased
overexpression	invasive growth: increased vegetative growth: increased
Large-scale survey
null	competitive fitness: decreased resistance to CTBT: decreased sporulation efficiency: increased starvation resistance: decreased vacuolar morphology: abnormal viable
overexpression	colony sectoring: increased vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	33 total interaction(s) for 30 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1
Genetic Interactions	Dosage Lethality: 2 Dosage Rescue: 7 Negative Genetic: 11 Phenotypic Suppression: 2 Positive Genetic: 3 Synthetic Growth Defect: 1 Synthetic Lethality: 3 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:583892 to 582990 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 14 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..903 583892..582990 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003276