RME1/YGR044C Summary Help

Standard Name RME1 1
Systematic Name YGR044C
Alias CSP1
Feature Type ORF, Verified
Description Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress (2, 3, 4)
Name Description Regulator of MEiosis 1
Chromosomal Location
ChrVII:583892 to 582990 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: 14 cM
Gene Ontology Annotations All RME1 GO evidence and references
  View Computational GO annotations for RME1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Targets 14 genes
Regulators 6 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
35 total interaction(s) for 32 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 2

Genetic Interactions
  • Dosage Lethality: 2
  • Dosage Rescue: 7
  • Negative Genetic: 11
  • Phenotypic Suppression: 2
  • Positive Genetic: 3
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 3
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 300
Molecular Weight (Da) 33,904
Isoelectric Point (pI) 7.08
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:583892 to 582990 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Genetic position: 14 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..903 583892..582990 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003276
References cited on this page View Complete Literature Guide for RME1
1) Kassir Y and Simchen G  (1976) Regulation of mating and meiosis in yeast by the mating-type region. Genetics 82(2):187-206
2) Covitz PA, et al.  (1991) The yeast RME1 gene encodes a putative zinc finger protein that is directly repressed by a1-alpha 2. Genes Dev 5(11):1982-9
3) Rine J, et al.  (1981) rme1 Mutation of Saccharomyces cerevisiae: map position and bypass of mating type locus control of sporulation. Mol Cell Biol 1(10):958-60
4) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76