ORM1/YGR038W Summary Help

Standard Name ORM1 1, 2
Systematic Name YGR038W
Feature Type ORF, Verified
Description Protein of unknown function; evolutionarily conserved, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; ORM1 has a paralog, ORM2, that arose from the whole genome duplication (3, 4, 5)
Chromosomal Location
ChrVII:560682 to 561350 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All ORM1 GO evidence and references
  View Computational GO annotations for ORM1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 77 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
Resources
102 total interaction(s) for 61 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 12
  • Affinity Capture-Western: 10
  • Biochemical Activity: 7
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 46
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 4
  • Positive Genetic: 6
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 2
  • Synthetic Rescue: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 222
Molecular Weight (Da) 25,245
Isoelectric Point (pI) 6.63
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:560682 to 561350 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..669 560682..561350 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003270
References cited on this page View Complete Literature Guide for ORM1
1) Mueller, L., et al.  (1996) RanBP3 is a nuclear Ran-GTP binding protein that forms a Ran-dependent complex with RCC1 in vivo and in vitro. Unpublished
2) SGD  (2009) Gene name standardized from a GenBank/EMBL/DDBJ record
3) Hjelmqvist L, et al.  (2002) ORMDL proteins are a conserved new family of endoplasmic reticulum membrane proteins. Genome Biol 3(6):RESEARCH0027
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Han S, et al.  (2010) Orm1 and Orm2 are conserved endoplasmic reticulum membrane proteins regulating lipid homeostasis and protein quality control. Proc Natl Acad Sci U S A 107(13):5851-6