Standard Name	MTL1 1
Systematic Name	YGR023W
Feature Type	ORF, Verified
Description	Putative plasma membrane sensor; involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; has structural and functional similarity to Mid2p; MTL1 has a paralog, MID2, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description	Mid-Two Like 1, 2

Chromosomal Location	ChrVII:529264 to 530919 | ORF Map | GBrowse

	View Computational GO annotations for MTL1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	cellular response to glucose starvation (IGI, IMP) cellular response to oxidative stress (IGI, IMP) fungal-type cell wall organization (IGI, IMP)
Cellular Component
Manually curated	integral to plasma membrane (ISS)

Classical genetics
null	actin cytoskeleton morphology: abnormal glycogen accumulation: decreased resistance to hydrogen peroxide: decreased resistance to sirolimus: decreased resistance to caffeine: decreased resistance to 1,1'-azobis(N,N-dimethylformamide): decreased
Large-scale survey
null	competitive fitness: normal resistance to benzo[a]pyrene: decreased resistance to amitrole: decreased resistance to cycloheximide: decreased viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	45 total interaction(s) for 33 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 Affinity Capture-Western: 2 PCA: 2 Protein-RNA: 2 Two-hybrid: 1
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 11 Negative Genetic: 12 Phenotypic Enhancement: 2 Phenotypic Suppression: 4 Positive Genetic: 3 Synthetic Growth Defect: 2 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:529264 to 530919 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1656 529264..530919 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003255