Standard Name	MSB2 1
Systematic Name	YGR014W
Feature Type	ORF, Verified
Description	Mucin family member involved in signaling; functions in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; is processed into secreted and cell-associated forms by the aspartyl protease, Yps1p; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate (2, 3, 4, 5, 6)
Name Description	Multicopy Suppressor of a Budding defect

Chromosomal Location	ChrVII:516943 to 520863 | ORF Map | GBrowse
	Genetic position: 2 cM

	View Computational GO annotations for MSB2
Molecular Function
Manually curated	osmosensor activity (IMP)
Biological Process
Manually curated	establishment of cell polarity (IGI, IMP) hyperosmotic response (IGI) osmosensory signaling pathway via Sho1 osmosensor (IGI) response to osmotic stress (IMP) signal transduction involved in filamentous growth (IEP, IGI, IMP)
Cellular Component
Manually curated	integral to plasma membrane (IMP, ISS) site of polarized growth (IDA)

Classical genetics
null	invasive growth: absent invasive growth: decreased
overexpression	cell shape: abnormal
Large-scale survey
null	auxotrophy N-acetyl ornithine accumulation: decreased competitive fitness: increased resistance to benzo[a]pyrene: decreased viable
overexpression	vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	61 total interaction(s) for 46 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 Affinity Capture-Western: 5 Biochemical Activity: 1 PCA: 4 Reconstituted Complex: 1 Two-hybrid: 10
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 5 Negative Genetic: 10 Phenotypic Enhancement: 2 Phenotypic Suppression: 7 Positive Genetic: 1 Synthetic Growth Defect: 1 Synthetic Haploinsufficiency: 2 Synthetic Lethality: 4 Synthetic Rescue: 6
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:516943 to 520863 | ORF Map | GBrowse
	Genetic position: 2 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3921 516943..520863 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003246