MSB2/YGR014W Summary Help

MSB2 BASIC INFORMATION

Standard Name MSB2 1
Systematic Name YGR014W
Feature Type ORF, Verified
Description Mucin family member involved in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate (2, 3, 4, 5)
Name Description Multicopy Suppressor of a Budding defect
GO Annotations All MSB2 GO evidence and references
    View Computational GO annotations for MSB2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All MSB2 Phenotype details and references
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Interactions MSB2 All interactions details and references
32 total interaction(s) for 25 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 4
  • Biochemical Activity: 2
  • PCA: 2
  • Reconstituted Complex: 1
  • Two-hybrid: 10
Genetic Interactions
  • Dosage Rescue: 5
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 5
  • Synthetic Lethality: 1
Sequence Information
ChrVII:516947 to 520867 | ORF Map | GBrowse
Gbrowse
Genetic position: 2 cM
Last Update Coordinates: 2004-07-20 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..3921 516947..520867 2004-07-20 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003246

MSB2 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for MSB2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MSB2]

1) Bender, A. and Pringle, J.  (1992) Personal Communication, Mortimer Map Edition 11
2) Bender A and Pringle JR  (1989) Multicopy suppression of the cdc24 budding defect in yeast by CDC42 and three newly identified genes including the ras-related gene RSR1. Proc Natl Acad Sci U S A 86(24):9976-80
3) O'Rourke SM and Herskowitz I  (2002) A third osmosensing branch in Saccharomyces cerevisiae requires the Msb2 protein and functions in parallel with the Sho1 branch. Mol Cell Biol 22(13):4739-49
4) Ubersax JA, et al.  (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
5) Cullen PJ, et al.  (2004) A signaling mucin at the head of the Cdc42- and MAPK-dependent filamentous growth pathway in yeast. Genes Dev 18(14):1695-708