STF2/YGR008C Summary 
| Standard Name | STF2 1 |
|---|---|
| Systematic Name | YGR008C |
| Feature Type | ORF, Verified |
| Description | Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to F0 sector of mitochondrial F1F0 ATPase in vitro and may modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress; STF2 has a paralog, TMA10, that arose from the whole genome duplication (1, 2, 3, 4, 5, 6) |
| Name Description | STabilizing Factor 7, 8 |
| Chromosomal Location | |
|---|---|
| Note: this feature is encoded on the Crick strand. | |
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Gene Ontology Annotations All STF2 GO evidence and references
| View Computational GO annotations for STF2 | |
| Molecular Function | |
| Manually curated |
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| Biological Process | |
| Manually curated | |
| Cellular Component | |
| Manually curated |
Mutant phenotypes All STF2 Phenotype evidence and references
| Classical genetics | |
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| null | |
| overexpression | |
| Large-scale survey | |
| null | |
| unspecified | |
| Resources |
interactions All STF2 Interaction evidence and references
| 15 total interaction(s) for 15 unique genes/features. | |
| Physical Interactions |
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| Genetic Interactions |
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| Resources |
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Expression Summary
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| Resources |
Protein Information All STF2 Protein evidence and references
| Localization | |
|---|---|
| Phosphorylation | PhosphoGRID | PhosphoPep Database |
| Structure | |
| Homologs |
sequence information
| Note: this feature is encoded on the Crick strand. | |||||||||||||
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| Last Update | Coordinates: 2011-02-03 | Sequence: 1996-07-31 | ||||||||||||
| Subfeature details |
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Analyze Sequence
| S288C only | |
|---|---|
| S288C vs. other species | |
| S288C vs. other strains |
Resources
| External Links | All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB |
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| Primary SGDID | S000003240 |
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References cited on this page View Complete Literature Guide for STF2
| 1) | Yoshida Y, et al. (1990) Isolation of a gene for a regulatory 15-kDa subunit of mitochondrial F1F0-ATPase and construction of mutant yeast lacking the protein. Eur J Biochem 192(1):49-53 |
| 2) | Dienhart M, et al. (2002) Formation of the yeast F1F0-ATP synthase dimeric complex does not require the ATPase inhibitor protein, Inh1. J Biol Chem 277(42):39289-95 |
| 3) | Hashimoto T, et al. (1990) Simultaneous bindings of ATPase inhibitor and 9K protein to F1F0-ATPase in the presence of 15K protein in yeast mitochondria. J Biochem 108(1):17-20 |
| 4) | Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61 |
| 5) | Lopez-Martinez G, et al. (2012) The STF2p Hydrophilin from Saccharomyces cerevisiae Is Required for Dehydration Stress Tolerance. PLoS One 7(3):e33324 |
| 6) | Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76 |
| 7) | Hashimoto T, et al. (1983) Binding properties of an intrinsic ATPase inhibitor and occurrence in yeast mitochondria of a protein factor which stabilizes and facilitates the binding of the inhibitor to F1F0-ATPase. J Biochem 94(3):715-20 |
| 8) | Hashimoto T, et al. (1984) Purification and properties of factors in yeast mitochondria stabilizing the F1F0-ATPase-inhibitor complex. J Biochem 95(1):131-6 |
