Standard Name	CUL3 1
Systematic Name	YGR003W
Feature Type	ORF, Verified
Description	Ubiquitin-protein ligase, forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3 (1, 2, 3, 4) Also known as: CULB
Name Description	CULlin 5
Gene Product Alias	CULLIN B

Chromosomal Location	ChrVII:500132 to 502366 | ORF Map | GBrowse

	View Computational GO annotations for CUL3
Molecular Function
Manually curated	ubiquitin-protein ligase activity (IDA)
Biological Process
Manually curated	protein ubiquitination involved in ubiquitin-dependent protein catabolic process (IMP) ubiquitin-dependent protein catabolic process (IC, ISS)
Cellular Component
Manually curated	Cul3-RING ubiquitin ligase complex (IDA, IMP)
High-throughput	cytoplasm (IDA) nucleus (IDA)

Classical genetics
null	viable
Large-scale survey
null	anaerobic growth: decreased competitive fitness: decreased haploinsufficient viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	19 total interaction(s) for 17 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-Western: 2 Biochemical Activity: 2 Co-purification: 2 Reconstituted Complex: 2 Two-hybrid: 2
Genetic Interactions	Negative Genetic: 5 Phenotypic Enhancement: 1 Positive Genetic: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:500132 to 502366 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2235 500132..502366 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003235