Standard Name	RTG2 1
Systematic Name	YGL252C
Feature Type	ORF, Verified
Description	Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p (1, 2, 3, 4, 5)
Name Description	ReTroGrade regulation 1

Chromosomal Location	ChrVII:27484 to 25718 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

Molecular Function
Manually curated	RNA polymerase II transcription factor binding transcription factor activity (IDA, IGI, IMP)
Biological Process
Manually curated	maintenance of DNA trinucleotide repeats (IMP) mitochondria-nucleus signaling pathway (IMP) negative regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging (IMP) nitrogen catabolite regulation of transcription from RNA polymerase II promoter (IMP) positive regulation of transcription from RNA polymerase II promoter (IDA, IGI, IMP) regulation of transcription from RNA polymerase II promoter (IMP) transcription factor import into nucleus (IMP)
Cellular Component
Manually curated	cytoplasm (IDA) SLIK (SAGA-like) complex (IDA) transcriptionally active chromatin (IDA)

Classical genetics
null	tellurium atom accumulation: decreased resistance to hydroxyurea: decreased
unspecified	utilization of carbon source: absent
Large-scale survey
null	glycogen accumulation: increased competitive fitness: decreased metal resistance: increased resistance to fenpropimorph: decreased resistance to caffeine: decreased resistance to cycloheximide: decreased resistance to camptothecin: decreased resistance to ethanol: decreased resistance to hydroxyurea: decreased resistance to wortmannin: decreased resistance to sirolimus: decreased resistance to sirolimus: increased resistance to nickel sulfate: increased resistance to fluconazole: decreased resistance to methyl methanesulfonate: decreased resistance to sodium selenide: decreased resistance to bleomycin: decreased toxin resistance: increased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	252 total interaction(s) for 170 unique genes/features.
Physical Interactions	Affinity Capture-MS: 39 Affinity Capture-Western: 10 Co-purification: 1 Reconstituted Complex: 1 Two-hybrid: 3
Genetic Interactions	Negative Genetic: 147 Phenotypic Enhancement: 1 Phenotypic Suppression: 7 Positive Genetic: 23 Synthetic Growth Defect: 12 Synthetic Lethality: 3 Synthetic Rescue: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:27484 to 25718 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1767 27484..25718 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003221