RTG2/YGL252C Summary Help

Standard Name RTG2 1
Systematic Name YGL252C
Feature Type ORF, Verified
Description Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p (1, 2, 3, 4, 5)
Name Description ReTroGrade regulation 1
Chromosomal Location
ChrVII:27484 to 25718 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All RTG2 GO evidence and references
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Classical genetics
null
unspecified
Large-scale survey
null
Resources
261 total interaction(s) for 172 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 42
  • Affinity Capture-Western: 13
  • Co-purification: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 3

Genetic Interactions
  • Negative Genetic: 148
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 8
  • Positive Genetic: 23
  • Synthetic Growth Defect: 13
  • Synthetic Lethality: 3
  • Synthetic Rescue: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 588
Molecular Weight (Da) 65,572
Isoelectric Point (pI) 7.96
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:27484 to 25718 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1767 27484..25718 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003221
References cited on this page View Complete Literature Guide for RTG2
1) Liao X and Butow RA  (1993) RTG1 and RTG2: two yeast genes required for a novel path of communication from mitochondria to the nucleus. Cell 72(1):61-71
2) Sekito T, et al.  (2000) Mitochondria-to-nuclear signaling is regulated by the subcellular localization of the transcription factors Rtg1p and Rtg3p. Mol Biol Cell 11(6):2103-15
3) Komeili A, et al.  (2000) Mechanism of metabolic control. Target of rapamycin signaling links nitrogen quality to the activity of the Rtg1 and Rtg3 transcription factors. J Cell Biol 151(4):863-78
4) Sekito T, et al.  (2002) RTG-dependent mitochondria-to-nucleus signaling is regulated by MKS1 and is linked to formation of yeast prion [URE3]. Mol Biol Cell 13(3):795-804
5) Liu Z, et al.  (2003) Retrograde signaling is regulated by the dynamic interaction between Rtg2p and Mks1p. Mol Cell 12(2):401-11