Standard Name	CSE1
Systematic Name	YGL238W
Alias	KAP109
Feature Type	ORF, Verified
Description	Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation (1, 2, 3)
Name Description	Chromosome SEgregation 2

Chromosomal Location	ChrVII:49552 to 52434 | ORF Map | GBrowse

	View Computational GO annotations for CSE1
Molecular Function
Manually curated	importin-alpha export receptor activity (IGI, IPI, ISS)
Biological Process
Manually curated	protein export from nucleus (IGI, IPI)
Cellular Component
Manually curated	nuclear envelope (IDA)
High-throughput	integral to membrane (ISM)

Classical genetics
conditional	chromosome segregation: abnormal cold sensitivity: increased nuclear export: absent nuclear import: absent resistance to nocodazole: decreased
null	inviable
overexpression	inviable
repressible	chromosome/plasmid maintenance: decreased
Large-scale survey
null	haploproficient inviable
reduction of function	competitive fitness: decreased
repressible	cell cycle progression in S phase: abnormal chromosome/plasmid maintenance: decreased mitochondrial morphology: abnormal
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	67 total interaction(s) for 42 unique genes/features.
Physical Interactions	Affinity Capture-MS: 12 Affinity Capture-RNA: 3 Affinity Capture-Western: 5 Co-crystal Structure: 1 Reconstituted Complex: 7 Two-hybrid: 11
Genetic Interactions	Dosage Rescue: 3 Negative Genetic: 10 Positive Genetic: 9 Synthetic Growth Defect: 4 Synthetic Lethality: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:49552 to 52434 | ORF Map | GBrowse
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2883 49552..52434 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003207