HAP2/YGL237C Summary Help

Standard Name HAP2 1, 2
Systematic Name YGL237C
Feature Type ORF, Verified
Description Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex; complex is heme-activated and glucose-repressed; complex is a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding (2, 3, 4, 5, 6)
Name Description Heme Activator Protein 1, 2
Chromosomal Location
ChrVII:53528 to 52731 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Genetic position: -148 cM
Gene Ontology Annotations All HAP2 GO evidence and references
  View Computational GO annotations for HAP2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 6 genes
Classical genetics
reduction of function
Large-scale survey
175 total interaction(s) for 132 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 39
  • Affinity Capture-RNA: 2
  • Reconstituted Complex: 8
  • Two-hybrid: 9

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 94
  • Phenotypic Enhancement: 1
  • Positive Genetic: 9
  • Synthetic Growth Defect: 8
  • Synthetic Lethality: 1
  • Synthetic Rescue: 2

Expression Summary
Length (a.a.) 265
Molecular Weight (Da) 29,867
Isoelectric Point (pI) 9.49
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrVII:53528 to 52731 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Genetic position: -148 cM
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..798 53528..52731 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003206
References cited on this page View Complete Literature Guide for HAP2
1) Guarente L, et al.  (1984) Distinctly regulated tandem upstream activation sites mediate catabolite repression of the CYC1 gene of S. cerevisiae. Cell 36(2):503-11
2) Pinkham JL and Guarente L  (1985) Cloning and molecular analysis of the HAP2 locus: a global regulator of respiratory genes in Saccharomyces cerevisiae. Mol Cell Biol 5(12):3410-6
3) Chodosh LA, et al.  (1988) A yeast and a human CCAAT-binding protein have heterologous subunits that are functionally interchangeable. Cell 53(1):25-35
4) Forsburg SL and Guarente L  (1989) Identification and characterization of HAP4: a third component of the CCAAT-bound HAP2/HAP3 heteromer. Genes Dev 3(8):1166-78
5) Olesen JT and Guarente L  (1990) The HAP2 subunit of yeast CCAAT transcriptional activator contains adjacent domains for subunit association and DNA recognition: model for the HAP2/3/4 complex. Genes Dev 4(10):1714-29
6) Pinkham JL, et al.  (1987) Sequence and nuclear localization of the Saccharomyces cerevisiae HAP2 protein, a transcriptional activator. Mol Cell Biol 7(2):578-85
7) McNabb DS, et al.  (1995) Cloning of yeast HAP5: a novel subunit of a heterotrimeric complex required for CCAAT binding. Genes Dev 9(1):47-58