MTO1/YGL236C Summary Help

Standard Name MTO1 1
Systematic Name YGL236C
Alias IPS1 2
Feature Type ORF, Verified
Description Mitochondrial protein; forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants (1, 3)
Name Description Mitochondrial Translation Optimization 1
Chromosomal Location
ChrVII:55796 to 53787 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All MTO1 GO evidence and references
  View Computational GO annotations for MTO1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 7 genes
Resources
Classical genetics
null
Large-scale survey
null
unspecified
Resources
120 total interaction(s) for 79 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1
  • Protein-RNA: 1

Genetic Interactions
  • Negative Genetic: 103
  • Phenotypic Enhancement: 1
  • Positive Genetic: 11
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 669
Molecular Weight (Da) 74,215
Isoelectric Point (pI) 8.33
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:55796 to 53787 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2004-07-15 | Sequence: 2004-07-15
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2010 55796..53787 2004-07-15 2004-07-15
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003205
References cited on this page View Complete Literature Guide for MTO1
1) Colby G, et al.  (1998) MTO1 codes for a mitochondrial protein required for respiration in paromomycin-resistant mutants of Saccharomyces cerevisiae. J Biol Chem 273(43):27945-52
2) Entian KD, et al.  (1999) Functional analysis of 150 deletion mutants in Saccharomyces cerevisiae by a systematic approach. Mol Gen Genet 262(4-5):683-702
3) Umeda N, et al.  (2005) Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs. Implications for the molecular pathogenesis of human mitochondrial diseases. J Biol Chem 280(2):1613-24