SEC15/YGL233W Summary Help

SEC15 BASIC INFORMATION

Standard Name SEC15 1
Systematic Name YGL233W
Feature Type ORF, Verified
Description Essential 113kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which mediates polarized targeting of vesicles to active sites of exocytosis; Sec15p associates with Sec4p and vesicles (2, 3)
Name Description SECretory 4
GO Annotations All SEC15 GO evidence and references
    View Computational GO annotations for SEC15
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All SEC15 Phenotype details and references
Classical genetics
conditional
reduction of function
repressible
Large-scale survey
null
overexpression
repressible
Interactions SEC15 All interactions details and references
182 total interaction(s) for 93 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 18
  • Affinity Capture-Western: 18
  • Co-fractionation: 6
  • Co-purification: 1
  • Reconstituted Complex: 4
  • Two-hybrid: 11
Genetic Interactions
  • Dosage Growth Defect: 3
  • Dosage Lethality: 4
  • Dosage Rescue: 17
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 89
  • Synthetic Rescue: 2
Sequence Information
ChrVII:59122 to 61854 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2004-07-15 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2733 59122..61854 2004-07-15 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003202

SEC15 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for SEC15

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SEC15]

1) Novick P, et al.  (1980) Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway. Cell 21(1):205-15
2) TerBush DR, et al.  (1996) The Exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae. EMBO J 15(23):6483-94
3) Guo W, et al.  (1999) The exocyst is an effector for Sec4p, targeting secretory vesicles to sites of exocytosis. EMBO J 18(4):1071-80
4) Novick P and Schekman R  (1979) Secretion and cell-surface growth are blocked in a temperature-sensitive mutant of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 76(4):1858-62