TAN1/YGL232W Summary Help

Standard Name TAN1 1
Systematic Name YGL232W
Feature Type ORF, Verified
Description Putative tRNA acetyltransferase; RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA; protein abundance increases in response to DNA replication stress (1, 2)
Name Description Trna AcetylatioN 1
Chromosomal Location
ChrVII:62075 to 63002 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All TAN1 GO evidence and references
  View Computational GO annotations for TAN1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
46 total interaction(s) for 35 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 8
  • Affinity Capture-RNA: 2

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 16
  • Phenotypic Suppression: 3
  • Positive Genetic: 3
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 2
  • Synthetic Rescue: 7

Resources
Expression Summary
histogram
Resources
Length (a.a.) 289
Molecular Weight (Da) 33,550
Isoelectric Point (pI) 8.51
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:62075 to 63002 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2004-07-15 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..57 62075..62131 2004-07-15 1996-07-31
Intron 58..115 62132..62189 2004-07-15 1996-07-31
CDS 116..928 62190..63002 2004-07-15 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003201
References cited on this page View Complete Literature Guide for TAN1
1) Johansson MJ and Bystrom AS  (2004) The Saccharomyces cerevisiae TAN1 gene is required for N4-acetylcytidine formation in tRNA. RNA 10(4):712-9
2) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76