EMC4/YGL231C Summary Help

Standard Name EMC4 1
Systematic Name YGL231C
Feature Type ORF, Verified
Description Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC-4, fly CG11137, human TMM85 (1, 2, 3)
Name Description ER Membrane protein Complex 1
Chromosomal Location
ChrVII:63620 to 63048 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All EMC4 GO evidence and references
  View Computational GO annotations for EMC4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
overexpression
Large-scale survey
null
Resources
75 total interaction(s) for 43 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 6
  • Biochemical Activity: 1

Genetic Interactions
  • Negative Genetic: 42
  • Phenotypic Enhancement: 12
  • Phenotypic Suppression: 4
  • Positive Genetic: 7
  • Synthetic Growth Defect: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 190
Molecular Weight (Da) 21,460
Isoelectric Point (pI) 10.45
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:63620 to 63048 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2004-07-15 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..573 63620..63048 2004-07-15 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003200
References cited on this page View Complete Literature Guide for EMC4
1) Jonikas MC, et al.  (2009) Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum. Science 323(5922):1693-7
2) Ring G, et al.  (2008) Transmembrane protein 85 from both human (TMEM85) and yeast (YGL231c) inhibit hydrogen peroxide mediated cell death in yeast. FEBS Lett 582(17):2637-42
3) Richard M, et al.  (2013) Biosynthesis of ionotropic acetylcholine receptors requires the evolutionarily conserved ER membrane complex. Proc Natl Acad Sci U S A 110(11):E1055-63