Standard Name	VRG4 1, 2
Systematic Name	YGL225W
Alias	VAN2 3 , GOG5 , LDB3 , VIG4 4
Feature Type	ORF, Verified
Description	Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi; VRG4 has a paralog, HVG1, that arose from the whole genome duplication (1, 2, 5, 6)
Name Description	Vandate Resistance Glycosylation 1

Chromosomal Location	ChrVII:76894 to 77907 | ORF Map | GBrowse

	View Computational GO annotations for VRG4
Molecular Function
Manually curated	GDP-mannose transmembrane transporter activity (IDA, IMP)
Biological Process
Manually curated	GDP-mannose transport (IMP)
Cellular Component
Manually curated	Golgi apparatus (IDA)
High-throughput	integral to membrane (ISM) mitochondrion (IDA)

Classical genetics
unspecified	sphingolipid accumulation: decreased endomembrane system morphology: abnormal flocculation: increased heat sensitivity: increased Suc2p modification: decreased Cts1p modification: decreased resistance to sodium orthovanadate: increased resistance to hygromycin B: decreased resistance to gentamycin: decreased resistance to kanamycin: decreased resistance to neomycin B sulfate: decreased survival rate in stationary phase: decreased thermotolerance: decreased
Large-scale survey
conditional	heat sensitivity: increased
null	inviable
reduction of function	competitive fitness: decreased resistance to methyl methanesulfonate: decreased
repressible	chromosome/plasmid maintenance: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	63 total interaction(s) for 39 unique genes/features.
Physical Interactions	Affinity Capture-MS: 4 Affinity Capture-RNA: 1 Co-purification: 1 PCA: 1 Two-hybrid: 6
Genetic Interactions	Negative Genetic: 49 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:76894 to 77907 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1014 76894..77907 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB

Primary SGDID	S000003193