Standard Name	COG1 1
Systematic Name	YGL223C
Alias	COD3 , LDB11 , SEC36 2
Feature Type	ORF, Verified
Description	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments (2, 3, 4)
Name Description	Conserved Oligomeric Golgi complex 2

Chromosomal Location	ChrVII:80365 to 79112 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for COG1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	CVT pathway (IMP) intra-Golgi vesicle-mediated transport (IGI, IPI) retrograde transport, vesicle recycling within Golgi (IMP)
Cellular Component
Manually curated	Golgi transport complex (IPI)

Classical genetics
null	chronological lifespan: increased heat sensitivity: increased vegetative growth: decreased rate viable
Large-scale survey
null	anaerobic growth: decreased bud morphology: abnormal glutathione excretion: increased competitive fitness: decreased dessication resistance: decreased haploinsufficient heat sensitivity: increased Can1p-GFP distribution: abnormal resistance to acrolein: decreased resistance to sorbate: decreased respiratory growth: decreased rate toxin resistance: decreased transposable element transposition: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	78 total interaction(s) for 44 unique genes/features.
Physical Interactions	Affinity Capture-MS: 17 Affinity Capture-RNA: 2 Affinity Capture-Western: 11 Reconstituted Complex: 3 Two-hybrid: 10
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 2 Negative Genetic: 6 Phenotypic Enhancement: 1 Synthetic Growth Defect: 11 Synthetic Lethality: 14
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:80365 to 79112 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1254 80365..79112 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003191