FRA2/YGL220W Summary Help

Standard Name FRA2 1
Systematic Name YGL220W
Alias AIM15 2
Feature Type ORF, Verified
Description Protein involved in negative regulation of iron regulon transcription; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel (1, 3, 4)
Name Description Fe Repressor of Activation 1
Chromosomal Location
ChrVII:82374 to 82736 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All FRA2 GO evidence and references
  View Computational GO annotations for FRA2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 91 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
23 total interaction(s) for 11 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 5
  • Affinity Capture-Western: 3
  • Reconstituted Complex: 4
  • Two-hybrid: 3

Genetic Interactions
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 120
Molecular Weight (Da) 14,102
Isoelectric Point (pI) 8.37
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:82374 to 82736 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..363 82374..82736 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003188
References cited on this page View Complete Literature Guide for FRA2
1) Kumanovics A, et al.  (2008) Identification of FRA1 and FRA2 as Genes Involved in Regulating the Yeast Iron Regulon in Response to Decreased Mitochondrial Iron-Sulfur Cluster Synthesis. J Biol Chem 283(16):10276-86
2) Hess DC, et al.  (2009) Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis. PLoS Genet 5(3):e1000407
3) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
4) Bishop AL, et al.  (2007) Phenotypic heterogeneity can enhance rare-cell survival in 'stress-sensitive' yeast populations. Mol Microbiol 63(2):507-20