Standard Name	MDM34 1
Systematic Name	YGL219C
Alias	MMM2
Feature Type	ORF, Verified
Description	Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth (1, 2, 3, 4)
Name Description	Mitochondrial Distribution and Morphology 1, 5

Chromosomal Location	ChrVII:84257 to 82878 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for MDM34
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	mitochondrion organization (IMP) phospholipid transport (IGI)
Cellular Component
Manually curated	ERMES complex (IPI) mitochondrial outer membrane (IDA)
High-throughput	cytoplasm (IDA) mitochondrial outer membrane (IDA) mitochondrion (IDA)

Classical genetics
null	cardiolipin accumulation: decreased tellurium atom accumulation: decreased phosphatidylethanolamine accumulation: increased mitochondrial morphology: abnormal resistance to fenpropimorph: decreased respiratory growth: absent
Large-scale survey
null	auxotrophy competitive fitness: decreased endocytosis: decreased haploproficient heat sensitivity: increased mitochondrial morphology: abnormal resistance to wortmannin: increased resistance to sirolimus: decreased resistance to quinine: decreased resistance to spermine: decreased resistance to hygromycin B: decreased respiratory growth: decreased rate stress resistance: increased transposable element transposition: increased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	102 total interaction(s) for 84 unique genes/features.
Physical Interactions	Affinity Capture-MS: 16 Affinity Capture-RNA: 2 Affinity Capture-Western: 2 PCA: 1 Protein-peptide: 1 Reconstituted Complex: 1 Two-hybrid: 1
Genetic Interactions	Dosage Lethality: 2 Dosage Rescue: 2 Negative Genetic: 29 Phenotypic Enhancement: 5 Phenotypic Suppression: 2 Positive Genetic: 9 Synthetic Growth Defect: 22 Synthetic Lethality: 5 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:84257 to 82878 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1380 84257..82878 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003187