MDM34/YGL219C Summary Help

Standard Name MDM34 1
Systematic Name YGL219C
Alias MMM2
Feature Type ORF, Verified
Description Mitochondrial component of the ERMES complex; links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; required for mitophagy (1, 2, 3, 4, 5)
Name Description Mitochondrial Distribution and Morphology 1, 6
Chromosomal Location
ChrVII:84257 to 82878 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All MDM34 GO evidence and references
  View Computational GO annotations for MDM34
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 1 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
104 total interaction(s) for 84 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 18
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 2
  • PCA: 1
  • Protein-peptide: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Lethality: 2
  • Dosage Rescue: 2
  • Negative Genetic: 29
  • Phenotypic Enhancement: 5
  • Phenotypic Suppression: 2
  • Positive Genetic: 9
  • Synthetic Growth Defect: 22
  • Synthetic Lethality: 5
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 459
Molecular Weight (Da) 51,990
Isoelectric Point (pI) 9.71
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:84257 to 82878 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1380 84257..82878 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003187
References cited on this page View Complete Literature Guide for MDM34
1) Youngman MJ, et al.  (2004) Mmm2p, a mitochondrial outer membrane protein required for yeast mitochondrial shape and maintenance of mtDNA nucleoids. J Cell Biol 164(5):677-88
2) Dimmer KS, et al.  (2005) Mdm31 and Mdm32 are inner membrane proteins required for maintenance of mitochondrial shape and stability of mitochondrial DNA nucleoids in yeast. J Cell Biol 168(1):103-15
3) Ota K, et al.  (2008) A proteomic screen reveals the mitochondrial outer membrane protein Mdm34p as an essential target of the F-box protein Mdm30p. Genes Cells 13(10):1075-85
4) Kornmann B, et al.  (2009) An ER-mitochondria tethering complex revealed by a synthetic biology screen. Science 325(5939):477-81
5) Bockler S and Westermann B  (2014) Mitochondrial ER Contacts Are Crucial for Mitophagy in Yeast. Dev Cell 28(4):450-8
6) Dimmer KS, et al.  (2002) Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae. Mol Biol Cell 13(3):847-53