CHC1/YGL206C Summary Help

CHC1 BASIC INFORMATION

Standard Name CHC1 1
Systematic Name YGL206C
Alias SWA5 2
Feature Type ORF, Verified
Description Clathrin heavy chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; two heavy chains form the clathrin triskelion structural component; the light chain (CLC1) is thought to regulate function (1, 3, 4)
Name Description Clathrin Heavy Chain 1
GO Annotations All CHC1 GO evidence and references
    View Computational GO annotations for CHC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All CHC1 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions CHC1 All interactions details and references
117 total interaction(s) for 64 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 23
  • Affinity Capture-Western: 20
  • Co-localization: 7
  • PCA: 10
  • Reconstituted Complex: 4
  • Two-hybrid: 3
Genetic Interactions
  • Dosage Rescue: 8
  • Phenotypic Enhancement: 7
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 24
  • Synthetic Lethality: 9
  • Synthetic Rescue: 1
Sequence Information
ChrVII:107508 to 102547 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: -133 cM
Last Update Coordinates: 2004-07-20 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..4962 107508..102547 2004-07-20 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003174

CHC1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
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  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for CHC1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CHC1]

1) Payne GS and Schekman R  (1985) A test of clathrin function in protein secretion and cell growth. Science 230(4729):1009-14
2) Chen CY and Graham TR  (1998) An arf1Delta synthetic lethal screen identifies a new clathrin heavy chain conditional allele that perturbs vacuolar protein transport in Saccharomyces cerevisiae. Genetics 150(2):577-89
3) Lemmon SK and Jones EW  (1987) Clathrin requirement for normal growth of yeast. Science 238(4826):504-9
4) Gruenberg J and Stenmark H  (2004) The biogenesis of multivesicular endosomes. Nat Rev Mol Cell Biol 5(4):317-23